Adipic acid

Modify Date: 2026-07-01 04:05:32

Adipic acid structure	Common Name	Adipic acid
	CAS Number	124-04-9	Molecular Weight	146.141
	Density	1.3±0.1 g/cm3	Boiling Point	338.5±15.0 °C at 760 mmHg
	Molecular Formula	C₆H₁₀O₄	Melting Point	151-154 °C(lit.)
	MSDS	Chinese USA	Flash Point	196 ºC
	Symbol	GHS07	Signal Word	Warning

Use of Adipic acid

Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Adipic acid
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
References	[1]. G.Frauendienst-Egger, Friedrich K. Trefz (2017). MetaGene: Metabolic & Genetic Information Center. METAGENE consortium.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.3±0.1 g/cm3
Boiling Point	338.5±15.0 °C at 760 mmHg
Melting Point	151-154 °C(lit.)
Molecular Formula	C₆H₁₀O₄
Molecular Weight	146.141
Flash Point	196 ºC
Exact Mass	146.057907
PSA	74.60000
LogP	0.08
Vapour density	5 (vs air)
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.476
InChIKey	WNLRTRBMVRJNCN-UHFFFAOYSA-N
SMILES	O=C(O)CCCCC(=O)O
Stability	Stable. Substances to be avoided include ammonia, strong oxidizing agents.
Water Solubility	1.44 g/100 mL (15 ºC)

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Adipic acid MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU8400000

CHEMICAL NAME :: Adipic acid

CAS REGISTRY NUMBER :: 124-04-9

BEILSTEIN REFERENCE NO. :: 1209788

LAST UPDATED :: 199712

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C6-H10-O4

MOLECULAR WEIGHT :: 146.16

WISWESSER LINE NOTATION :: QV4VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,315,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(9),72,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Blood - hemorrhage

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 5,759,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 5,759,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Blood - hemorrhage

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 5,759,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(9),72,1983 *** REVIEWS *** ACGIH TLV-TWA 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 4 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84427 No. of Facilities: 1068 (estimated) No. of Industries: 21 No. of Occupations: 42 No. of Employees: 14846 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84427 No. of Facilities: 6259 (estimated) No. of Industries: 54 No. of Occupations: 66 No. of Employees: 140635 (estimated) No. of Female Employees: 77996 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36
Safety Phrases	S26
RIDADR	UN 9077
WGK Germany	1
RTECS	AU8400000
Hazard Class	9.2
HS Code	2917120001

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:108-93-0 Cyclohexanol CAS#:108-94-1 Cyclohexanone CAS#:110-82-7 cyclohexane CAS#:110-83-8 Cyclohexene
CAS#:931-17-9 1,2-Cyclohexanediol CAS#:533-60-8 2-Hydroxycycloh... CAS#:6338-43-8 Oxolane-2,5-dic... CAS#:765-87-7 1,2-Cyclohexanedione
CAS#:286-20-4 Cyclohexene oxide CAS#:502-44-3 6-Hexanolactone
DownStream 9
CAS#:105-97-5 Hexanedioic aci... CAS#:105-02-2 Hexanedioic aci... CAS#:1071-71-2 Ethyl6-chloro-6... CAS#:108-63-4 DICAPRYL ADIPATE
CAS#:4435-50-1 butane-1,2,3-triol CAS#:3068-00-6 Q2YQ1Q CAS#:107-21-1 Ethylene glycol CAS#:542-32-5 α-Aminoadipic acid
CAS#:3375-38-0 1,4-Dibenzoylbutane

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2917120001
Summary	HS: 2917120001 adipic acid Tax rebate rate:13.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

Prediction of skeletal muscle and fat mass in patients with advanced cancer using a metabolomic approach.

J. Nutr. 142(1) , 14-21, (2012)

Urine and plasma metabolites originate from endogenous metabolic pathways in different organs and exogenous sources (diet). Urine and plasma were obtained from advanced cancer patients and investigate...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve...
Source: NCGC
Target: N/A
External Id: OBG420

Total 301, Current Page 1 of 31

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Acifloctin

1,6-Hexanedioic acid

Adilactetten

1,4-Butanedicarboxylic acid

EINECS 204-673-3

hexane-1,6-dicarboxylic acid

hexanedioic acid

Acinetten

Adipic acid

MFCD00004420

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the downstream products of Adipic acid?

A: Related downstream products(CAS) of Adipic acid: 105-97-5;105-02-2;1071-71-2;108-63-4;4435-50-1;3068-00-6;107-21-1;542-32-5;3375-38-0.

Q: How is the water solubility of Adipic acid?

A: Water solubility of Adipic acid: 1.44 g/100 mL (15 ºC).

Q: What are the uses of Adipic acid?

A: Main uses of Adipic acid: Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.

Q: What is the InChIKey of Adipic acid?

A: InChIKey of Adipic acid is WNLRTRBMVRJNCN-UHFFFAOYSA-N.

Q: What is the melting point of Adipic acid?

A: Melting point of Adipic acid is 151-154 °C(lit.).

Q: What is the molecular weight of Adipic acid?

A: Molecular weight of Adipic acid is 146.141.

Q: What is the English name of Adipic acid?

A: The English name of Adipic acid is Adipic acid.

Q: What is the CAS number of Adipic acid?

A: CAS number of Adipic acid is 124-04-9.

Q: What English synonyms does Adipic acid have?

A: English synonyms of Adipic acid: Acifloctin, 1,6-Hexanedioic acid, Adilactetten, 1,4-Butanedicarboxylic acid, EINECS 204-673-3, hexane-1,6-dicarboxylic acid, hexanedioic acid, Acinetten, Adipic acid, MFCD00004420.

Q: What is the polar surface area (PSA) of Adipic acid?

A: Polar surface area (PSA) of Adipic acid is 74.60000.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Adipic acid
Price: Check
Purity: 99.5%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Adipic acid suppliers in China
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Adipic acid suppliers

Price: ￥76.4/500g

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.