4-cumylphenol

Modify Date: 2025-08-24 17:58:11

4-cumylphenol Structure
4-cumylphenol structure
Common Name 4-cumylphenol
CAS Number 599-64-4 Molecular Weight 212.28700
Density 1,115 g/cm3 Boiling Point 335 °C
Molecular Formula C15H16O Melting Point 72-75 °C
MSDS Chinese USA Flash Point 160 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 4-cumylphenol


4-Cumylphenol is a polycarbonate chain terminator. 4-Cumylphenol is widely used as a material for polycarbonate plastics, surfactants, fungicides and preservatives. 4-Cumylphenol also induces lipid accumulation in mouse adipocytes[1][2][3].

 Names

Name 4-cumylphenol
Synonym More Synonyms

 4-cumylphenol Biological Activity

Description 4-Cumylphenol is a polycarbonate chain terminator. 4-Cumylphenol is widely used as a material for polycarbonate plastics, surfactants, fungicides and preservatives. 4-Cumylphenol also induces lipid accumulation in mouse adipocytes[1][2][3].
Related Catalog
In Vitro 4-Cumylphenol (1, 5, 10, 20, 40 µM; 6 days) increase lipid accumulation in 3 T3-L1 cells[3]. Cell Viability Assay[3] Cell Line: 3 T3-L1 cells Concentration: 1, 5, 10, 20, 40 µM Incubation Time: 6 days Result: Increase lipid accumulation, which peaked at10 μM with a 204% increase.
References

[1]. Yue W, et al. Biodegradation of bisphenol-A polycarbonate plastic by Pseudoxanthomonas sp. strain NyZ600. J Hazard Mater. 2021 Aug 15;416:125775.

[2]. Chiha M, et al. Sonolytic degradation of endocrine disrupting chemical 4-cumylphenol in water. Ultrason Sonochem. 2011 Sep;18(5):943-50.

[3]. Ramskov Tetzlaff CN, Svingen T, et al. Bisphenols B, E, F, and S and 4-cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A. Environ Toxicol. 2020 May;35(5):543-552.

 Chemical & Physical Properties

Density 1,115 g/cm3
Boiling Point 335 °C
Melting Point 72-75 °C
Molecular Formula C15H16O
Molecular Weight 212.28700
Flash Point 160 °C
Exact Mass 212.12000
PSA 20.23000
LogP 3.71810
Index of Refraction 1.587
Stability Stable. Incompatible with oxidizing agents, acid chlorides, acid anhydrides. Combustible.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SL1942450
CHEMICAL NAME :
Phenol, p-(alpha,alpha-dimethylbenzyl)-
CAS REGISTRY NUMBER :
599-64-4
BEILSTEIN REFERENCE NO. :
1870517
LAST UPDATED :
199710
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C15-H16-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
335 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 12(12),44,1968

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S24/25-S37/39-S26
RIDADR NONH for all modes of transport
RTECS SL1942450

 Synthetic Route

 Articles6

More Articles
Degradation and toxicity reduction of the endocrine disruptors nonylphenol, 4-tert-octylphenol and 4-cumylphenol by the non-ligninolytic fungus Umbelopsis isabellina.

Bioresour. Technol. 200 , 223-9, (2015)

Nonylphenol (NP), 4-tert-octylphenol (4-t-OP) and 4-cumylphenol (4-CP) are pollutants that are known as endocrine disruptors mainly due to their estrogen-mimicking activity. These phenolic substances ...

Occurrence, removal, and fate of progestogens, androgens, estrogens, and phenols in six sewage treatment plants around Dianchi Lake in China.

Environ. Sci. Pollut. Res. Int. 21(22) , 12898-908, (2014)

The occurrence and behavior of endocrine disrupting chemicals (EDCs) in sewage treatment plants (STPs), especially estrogens and phenols, have been closely concerned in previous studies. However, the ...

Double salts of ionic-liquid-based surfactants in microextraction: application of their mixed hemimicelles as novel sorbents in magnetic-assisted micro-dispersive solid-phase extraction for the determination of phenols.

Anal. Bioanal. Chem 407 , 8753-64, (2015)

The use of mixed hemimicelles of ionic liquid (IL)-based surfactants in a magnetic-based micro-dispersive solid-phase extraction (m-μdSPE) approach is described. Not only is the symmetric monocationic...

 Synonyms

P-CUMYLPHENOL
AURORA 4778
paracumilphenol
PARA-CUMYLPHENOL
PCP
Cumyl phenol
EINECS 209-968-0
MFCD00002365
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