Creatinine

Modify Date: 2024-01-02 10:04:40

Creatinine Structure
Creatinine structure
 Common Name Creatinine
CAS Number 60-27-5 Molecular Weight 113.118
Density 1.5±0.1 g/cm3 Boiling Point 184.3±23.0 °C at 760 mmHg
Molecular Formula C4H7N3O Melting Point 295 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 65.3±22.6 °C

 Use of Creatinine


Creatinine(NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.Target: OthersCreatinine is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass). Creatine is synthesized primarily in the liver from the methylation of glycocyamine (guanidino acetate, synthesized in the kidney from the amino acids arginine and glycine) by S-adenosyl methionine. It is then transported through blood to the other organs, muscle, and brain, where, through phosphorylation, it becomes the high-energy compound phosphocreatine. During the reaction, creatine and phosphocreatine are catalyzed by creatine kinase, and a spontaneous conversion to creatinine may occur [1]. Creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR), an important clinical index of renal function [2].

 Names

Name creatinine
Synonym More Synonyms

 Creatinine Biological Activity

Description Creatinine(NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.Target: OthersCreatinine is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass). Creatine is synthesized primarily in the liver from the methylation of glycocyamine (guanidino acetate, synthesized in the kidney from the amino acids arginine and glycine) by S-adenosyl methionine. It is then transported through blood to the other organs, muscle, and brain, where, through phosphorylation, it becomes the high-energy compound phosphocreatine. During the reaction, creatine and phosphocreatine are catalyzed by creatine kinase, and a spontaneous conversion to creatinine may occur [1]. Creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR), an important clinical index of renal function [2].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Allen, P.J., Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value. Neurosci Biobehav Rev, 2012. 36(5): p. 1442-62.

[2]. Levey, A.S., et al., Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med, 2006. 145(4): p. 247-54.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 184.3±23.0 °C at 760 mmHg
Melting Point 295 °C (dec.)(lit.)
Molecular Formula C4H7N3O
Molecular Weight 113.118
Flash Point 65.3±22.6 °C
Exact Mass 113.058914
PSA 58.69000
LogP -1.68
Vapour Pressure 0.2±0.8 mmHg at 25°C
Index of Refraction 1.651
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility SOLUBLE

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R34
Safety Phrases S26-S36/37/39-S45-S24/25
RIDADR UN 1789 8/PG 3
WGK Germany 3
HS Code 2933290090

 Customs

HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

Creatinine,heated
Creatinine
1-Methylglycocyamidine
4H-Imidazol-4-one,2-amino-1,5-dihydro-1-methyl
2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one
[3H]-Creatinine
2-amino-1-methylimidazolin-4-one
2-amino-3-methyl-4H-imidazol-5-one
2-Amino-1-methyl-1,5-dihydroimidazol-4-one
1-methyl-2-amino-1,5-dihydroimidazol-4-one
EINECS 200-466-7
MFCD00059730
1-Methylhydantoin-2-imide
2-Amino-1-methyl-1,5-dihydro-4H-imidazol-4-one
[14C]-Creatinine
4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-
2-imino-1-methylimidazolidin-4-one
2-Imino-N-methylhydantoin
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