1-α,25-Dihydroxyvitamin D2

Modify Date: 2024-01-10 11:17:18

1-α,25-Dihydroxyvitamin D2 structure	Common Name	1-α,25-Dihydroxyvitamin D2
	CAS Number	60133-18-8	Molecular Weight	428.647
	Density	1.1±0.1 g/cm3	Boiling Point	577.7±50.0 °C at 760 mmHg
	Molecular Formula	C₂₈H₄₄O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	242.5±24.7 °C
	Symbol	GHS02, GHS07	Signal Word	Danger

Use of 1-α,25-Dihydroxyvitamin D2

Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a active metabolite of vitamin D2. IC50 value: Target: Ercalcitriol (1α,25-Dihydroxy Vitamin D2) exhibits equipotent antirachitic activity in rats as calcitriol. Ercalcitriol(1α,25-Dihydroxy Vitamin D2) is a VDR-like Receptors

Name	1α,25-dihydroxyvitamin D2
Synonym	More Synonyms

Description	Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a active metabolite of vitamin D2. IC50 value: Target: Ercalcitriol (1α,25-Dihydroxy Vitamin D2) exhibits equipotent antirachitic activity in rats as calcitriol. Ercalcitriol(1α,25-Dihydroxy Vitamin D2) is a VDR-like Receptors
Related Catalog	Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease
References	[1]. Mawer EB, Berry JL, Cundall JP, Still PE, White A.A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta. 1990 Oct 15;190(3):199-209. [2]. Rambeck et al (1984) Biological activity of 1 alpha,25-dihydroxyergocalciferol in rachitic chicks and in rats. Int.J.Vitamin.Nutr.Res. 54 135. [3]. Shamik J. Parikh, Marni Edelman, Gabriel I. Uwaifo et al. The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults. The Journal of Clinical Endocrinology & Metabolism March 1, 2004 vol. 89 no. 3 1196-1199 [4]. Daniel W. Coyne, Marvin Grieff, Shubhada N. Ahya et al. Differential effects of acute administration of 19-Nor-1,25-dihydroxy-vitamin D2 and 1,25-dihydroxy-vitamin D3 on serum calcium and phosphorus in hemodialysis patients. American Journal of Kidney Diseases. December 2002,Volume 40, Issue 6 , Pages 1283-1288

Description

Related Catalog

Signaling Pathways >> Vitamin D Related >> VD/VDR

Research Areas >> Metabolic Disease

References

[1]. Mawer EB, Berry JL, Cundall JP, Still PE, White A.A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta. 1990 Oct 15;190(3):199-209.

[2]. Rambeck et al (1984) Biological activity of 1 alpha,25-dihydroxyergocalciferol in rachitic chicks and in rats. Int.J.Vitamin.Nutr.Res. 54 135.

[3]. Shamik J. Parikh, Marni Edelman, Gabriel I. Uwaifo et al. The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults. The Journal of Clinical Endocrinology & Metabolism March 1, 2004 vol. 89 no. 3 1196-1199

[4]. Daniel W. Coyne, Marvin Grieff, Shubhada N. Ahya et al. Differential effects of acute administration of 19-Nor-1,25-dihydroxy-vitamin D2 and 1,25-dihydroxy-vitamin D3 on serum calcium and phosphorus in hemodialysis patients. American Journal of Kidney Diseases. December 2002,Volume 40, Issue 6 , Pages 1283-1288

Density	1.1±0.1 g/cm3
Boiling Point	577.7±50.0 °C at 760 mmHg
Molecular Formula	C₂₈H₄₄O₃
Molecular Weight	428.647
Flash Point	242.5±24.7 °C
Exact Mass	428.329041
PSA	60.69000
LogP	6.15
Vapour Pressure	0.0±3.6 mmHg at 25°C
Index of Refraction	1.554
Storage condition	−20°C

1-α,25-Dihydroxyvitamin D2 MSDS(Chinese)

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H319
Precautionary Statements	P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R23/24/25;R63
Safety Phrases	36/37-45
RIDADR	UN 2811
WGK Germany	3

Precursor 5
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1α,25-dihydroxyergocalciferol

1alpha,25-dihydroxyvitamin D2

1α,25-Dihydroxy Vitamin D2

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1α,25-Dihydroxycalciferol

Ercalcitriol