R306465
Modify Date: 2025-08-25 01:08:04
R306465 structure
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Common Name | R306465 | ||
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| CAS Number | 604769-01-9 | Molecular Weight | 413.45 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C19H19N5O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of R306465JNJ-16241199 is an orally active, selective hydroxamate-based histone deacetylase (HDAC) inhibitor, with the IC50 of 3.3 nM and 23 nM for HDAC1 and HDAC8, respectively. JNJ-16241199 induces histone 3 acetylation and strongly increases the expression of p21waf1, cip1 in A2780 ovarian carcinoma cells. JNJ-16241199 induces cell apoptosis and shows anticancer activity in a broad spectrum of human malignancies. JNJ-16241199 can be used for cancer study[1]. |
| Name | N-hydroxy-2-(4-naphthalen-2-ylsulfonylpiperazin-1-yl)pyrimidine-5-carboxamide |
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| Synonym | More Synonyms |
| Description | JNJ-16241199 is an orally active, selective hydroxamate-based histone deacetylase (HDAC) inhibitor, with the IC50 of 3.3 nM and 23 nM for HDAC1 and HDAC8, respectively. JNJ-16241199 induces histone 3 acetylation and strongly increases the expression of p21waf1, cip1 in A2780 ovarian carcinoma cells. JNJ-16241199 induces cell apoptosis and shows anticancer activity in a broad spectrum of human malignancies. JNJ-16241199 can be used for cancer study[1]. |
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| Related Catalog | |
| Target |
HDAC1:3.3 nM (IC50) HDAC8:23 nM (IC50) |
| References |
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C19H19N5O4S |
| Molecular Weight | 413.45 |
| Exact Mass | 413.115784 |
| PSA | 124.11000 |
| LogP | 2.06 |
| Index of Refraction | 1.689 |
| InChIKey | MUTBJZVSRNUIHA-UHFFFAOYSA-N |
| SMILES | O=C(NO)c1cnc(N2CCN(S(=O)(=O)c3ccc4ccccc4c3)CC2)nc1 |
| HS Code | 2933990090 |
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| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| N-Hydroxy-2-[4-(2-naphthylsulfonyl)-1-piperazinyl]-5-pyrimidinecarboxamide |
| 5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- |
| unii-5wd7kk1iiq |
| R306465 |
| JNJ-16241199 |