AZ10606120 dihydrochloride

Modify Date: 2024-01-13 18:16:24

AZ10606120 dihydrochloride Structure
AZ10606120 dihydrochloride structure
Common Name AZ10606120 dihydrochloride
CAS Number 607378-18-7 Molecular Weight 495.485
Density N/A Boiling Point N/A
Molecular Formula C25H36Cl2N4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AZ10606120 dihydrochloride


AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1].

 Names

Name N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride,AZ 10606120 dihydrochloride
Synonym More Synonyms

 AZ10606120 dihydrochloride Biological Activity

Description AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1].
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Target

IC50: ~10 nM (P2X7R)[1]

References

[1]. Allsopp RC, et al. Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120. Sci Rep. 2017 Apr 7;7(1):725.

 Chemical & Physical Properties

Molecular Formula C25H36Cl2N4O2
Molecular Weight 495.485
Exact Mass 494.221527

 Synonyms

2-(Adamantan-1-yl)-N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)quinolin-5-yl]acetamide dihydrochloride
2-(Adamantan-1-yl)-N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)-5-quinolinyl]acetamide dihydrochloride
Tricyclo[3.3.1.1]decane-1-acetamide, N-[2-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-, hydrochloride (1:2)
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