Quinine Hydrochloride Dihydrate

Modify Date: 2024-01-03 06:14:06

Quinine Hydrochloride Dihydrate Structure
Quinine Hydrochloride Dihydrate structure
 Common Name Quinine Hydrochloride Dihydrate
CAS Number 6119-47-7 Molecular Weight 396.908
Density N/A Boiling Point 633ºC at 760 mmHg
Molecular Formula C20H29ClN2O4 Melting Point 115-116 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 122 °C
Symbol GHS07 GHS08
GHS07, GHS08		 Signal Word Danger

 Use of Quinine Hydrochloride Dihydrate


Quinine Hydrochloride Dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste.Target: AntiparasiticQuinine is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), and anti-inflammatory properties and a bitter taste. It is a stereoisomer of quinidine, which, unlike quinine, is an antiarrhythmic. Quinine contains two major fused-ring systems: the aromatic quinoline and the bicyclic quinuclidine. In patients with cerebral malaria receiving the standard dose of 10 mg/kg every eight hours, plasma quinine concentrations consistently exceeded 10 mg/liter, reaching a peak 60 ± 25 hours (mean ± 1 S.D.) after treatment was begun and then declining. Quinine total clearances (CI) and total apparent volumes of distribution (Vd) were significantly lower than in uncomplicated malaria (CI, 0.92 ± 0.42 compared with 1.35 ± 0.6 ml/min/kg, p = 0.03; Vd, 1.18 ± 0.37 compared with 1.67 ± 0.34 liter/kg, p = 0.0013) [1].

 Names

Name Quinine hydrochloride dihydrate
Synonym More Synonyms

 Quinine Hydrochloride Dihydrate Biological Activity

Description Quinine Hydrochloride Dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste.Target: AntiparasiticQuinine is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), and anti-inflammatory properties and a bitter taste. It is a stereoisomer of quinidine, which, unlike quinine, is an antiarrhythmic. Quinine contains two major fused-ring systems: the aromatic quinoline and the bicyclic quinuclidine. In patients with cerebral malaria receiving the standard dose of 10 mg/kg every eight hours, plasma quinine concentrations consistently exceeded 10 mg/liter, reaching a peak 60 ± 25 hours (mean ± 1 S.D.) after treatment was begun and then declining. Quinine total clearances (CI) and total apparent volumes of distribution (Vd) were significantly lower than in uncomplicated malaria (CI, 0.92 ± 0.42 compared with 1.35 ± 0.6 ml/min/kg, p = 0.03; Vd, 1.18 ± 0.37 compared with 1.67 ± 0.34 liter/kg, p = 0.0013) [1].
Related Catalog
References

[1]. White, N.J., et al., Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria. Am J Med, 1982. 73(4): p. 564-72.

 Chemical & Physical Properties

Boiling Point 633ºC at 760 mmHg
Melting Point 115-116 °C (dec.)(lit.)
Molecular Formula C20H29ClN2O4
Molecular Weight 396.908
Flash Point 122 °C
Exact Mass 396.181580
PSA 64.05000
LogP 3.78450
Index of Refraction -250 ° (C=2, EtOH)
Storage condition Store at -20°C

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H302-H317-H334
Precautionary Statements P261-P280-P342 + P311
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22;R36/37/38
Safety Phrases S22-S36/37-S45-S36/37/39-S26
RIDADR 1544
WGK Germany 3
RTECS VA7700000
HS Code 29392000

 Customs

HS Code 29392000

 Articles7

More Articles
Photostability profiles of the experimental antimetastatic ruthenium complex NAMI-A.

J. Pharm. Biomed. Anal. 30(4) , 1287-96, (2002)

NAMI-A is a novel ruthenium complex with selective activity against metastases currently in Phase I clinical trials in The Netherlands. The photostability of this new agent in solid state and in solut...

Quinine blocks a calcium-activated potassium conductance in mammalian enteric neurones.

Br. J. Pharmacol. 83(1) , 3-5, (1984)

Quinine (100 microM) abolished the slow calcium-dependent afterhyperpolarization which occurs after an action potential in some neurones of the guinea-pig myenteric and submucous plexus. This occurred...

Treatment of severe malaria.

J. R. Soc. Med. 82 Suppl 17 , 44-50; discussion 50-1, (1989)

In the treatment of severe Plasmodium falciparum infection antimalarial drugs should, ideally, be given by controlled rate intravenous infusion until the patient is able to swallow tablets. In cases w...

 Synonyms

Quinine hydrochloride,(R)-(6-Methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanolhydrochloride
EINECS 231-437-7
MFCD00151248
Quinine monohydrochloride dihydrate
Quinine Hydrochloride Dihydrate
Cinchonan-9-ol, 6'-methoxy-, (8α,9R)-, hydrochloride, hydrate (1:1:2)
(8α,9R)-6'-Methoxycinchonan-9-ol hydrochloride dihydrate
Quinine (hydrochloride dihydrate)
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Quinine Hydrochloride Dihydrate suppliers

Price: $79/10mM*1mLinDMSO

Reference only. check more Quinine Hydrochloride Dihydrate price

Related Compounds: More...
quinine hydrochloride dihydrate
130-89-2
HARMINE HYDROCHLORIDE DIHYDRATE
6028-02-0
HARMALINE HYDROCHLORIDE DIHYDRATE
6027-98-1
Akuammicine hydrochloride dihydrate [MI]
25530-64-7
Harmaline hydrochloride dihydrate
63885-08-5
HARMALOL HYDROCHLORIDE DIHYDRATE
6028-00-8
Terazosin hydrochloride dihydrate
70024-40-7
harmol hydrochloride dihydrate
149022-16-2
(4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol,dihydrate,hydrochloride
1228646-70-5
2-{[1-(2-Hydroxycyclopentyl)azetidin-3-yl]methyl}-6-(pyridin-3-yl)-2,3-dihydropyridazin-3-one
2201543-48-6
Methyl 1,4-thiazepane-6-carboxylate
1909311-82-5
5-[2-[(Methylsulfonyl)oxy]ethyl]-1(3h)-isobenzofuranone
1255209-27-8
2,4-Dimethyl-6-(pyridin-3-yl)aniline
1296770-58-5
2,2'-(2,5-Di(hex-5-en-1-yl)-1,4-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
1462818-84-3
2-(4-Bromo-2-nitrophenyl)pyridine
1262802-01-6
4-{5H,6H,7H-pyrrolo[2,3-d]pyrimidin-4-yl}morpholine
2060039-12-3
Methyl 4-amino-3-isopropylbenzoate
860694-25-3
6-Cyclopropyl-2-{2-oxo-2-[4-(pyridin-2-yl)piperazin-1-yl]ethyl}-2,3-dihydropyridazin-3-one
2034535-77-6
1-methyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-Pyrazole
1607838-15-2
Chemsrc provides Quinine Hydrochloride Dihydrate(CAS#:6119-47-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Quinine Hydrochloride Dihydrate are included as well.>> amp version: Quinine Hydrochloride Dihydrate

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved