Quinine Hydrochloride Dihydrate

Modify Date: 2025-08-22 22:21:56

Quinine Hydrochloride Dihydrate Structure
Quinine Hydrochloride Dihydrate structure
 Common Name Quinine Hydrochloride Dihydrate
CAS Number 6119-47-7 Molecular Weight 396.908
Density N/A Boiling Point 633ºC at 760 mmHg
Molecular Formula C20H29ClN2O4 Melting Point 115-116 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 122 °C
Symbol GHS07 GHS08
GHS07, GHS08		 Signal Word Danger

 Use of Quinine Hydrochloride Dihydrate


Quinine Hydrochloride Dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste.Target: AntiparasiticQuinine is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), and anti-inflammatory properties and a bitter taste. It is a stereoisomer of quinidine, which, unlike quinine, is an antiarrhythmic. Quinine contains two major fused-ring systems: the aromatic quinoline and the bicyclic quinuclidine. In patients with cerebral malaria receiving the standard dose of 10 mg/kg every eight hours, plasma quinine concentrations consistently exceeded 10 mg/liter, reaching a peak 60 ± 25 hours (mean ± 1 S.D.) after treatment was begun and then declining. Quinine total clearances (CI) and total apparent volumes of distribution (Vd) were significantly lower than in uncomplicated malaria (CI, 0.92 ± 0.42 compared with 1.35 ± 0.6 ml/min/kg, p = 0.03; Vd, 1.18 ± 0.37 compared with 1.67 ± 0.34 liter/kg, p = 0.0013) [1].

 Names

Name Quinine hydrochloride dihydrate
Synonym More Synonyms

 Quinine Hydrochloride Dihydrate Biological Activity

Description Quinine Hydrochloride Dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste.Target: AntiparasiticQuinine is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), and anti-inflammatory properties and a bitter taste. It is a stereoisomer of quinidine, which, unlike quinine, is an antiarrhythmic. Quinine contains two major fused-ring systems: the aromatic quinoline and the bicyclic quinuclidine. In patients with cerebral malaria receiving the standard dose of 10 mg/kg every eight hours, plasma quinine concentrations consistently exceeded 10 mg/liter, reaching a peak 60 ± 25 hours (mean ± 1 S.D.) after treatment was begun and then declining. Quinine total clearances (CI) and total apparent volumes of distribution (Vd) were significantly lower than in uncomplicated malaria (CI, 0.92 ± 0.42 compared with 1.35 ± 0.6 ml/min/kg, p = 0.03; Vd, 1.18 ± 0.37 compared with 1.67 ± 0.34 liter/kg, p = 0.0013) [1].
Related Catalog
References

[1]. White, N.J., et al., Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria. Am J Med, 1982. 73(4): p. 564-72.

 Chemical & Physical Properties

Boiling Point 633ºC at 760 mmHg
Melting Point 115-116 °C (dec.)(lit.)
Molecular Formula C20H29ClN2O4
Molecular Weight 396.908
Flash Point 122 °C
Exact Mass 396.181580
PSA 64.05000
LogP 3.78450
Index of Refraction -250 ° (C=2, EtOH)
Storage condition Store at -20°C

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H302-H317-H334
Precautionary Statements P261-P280-P342 + P311
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22;R36/37/38
Safety Phrases S22-S36/37-S45-S36/37/39-S26
RIDADR 1544
WGK Germany 3
RTECS VA7700000
HS Code 29392000

 Customs

HS Code 29392000

 Articles7

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 Synonyms

Quinine hydrochloride,(R)-(6-Methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanolhydrochloride
EINECS 231-437-7
MFCD00151248
Quinine monohydrochloride dihydrate
Quinine Hydrochloride Dihydrate
Cinchonan-9-ol, 6'-methoxy-, (8α,9R)-, hydrochloride, hydrate (1:1:2)
(8α,9R)-6'-Methoxycinchonan-9-ol hydrochloride dihydrate
Quinine (hydrochloride dihydrate)
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