Quinine sulfate dihydrate

Modify Date: 2024-01-02 07:02:09

Quinine sulfate dihydrate Structure
Quinine sulfate dihydrate structure
Common Name Quinine sulfate dihydrate
CAS Number 6119-70-6 Molecular Weight 458.53
Density N/A Boiling Point 495.9ºC at 760 mmHg
Molecular Formula C20H30N2O8S Melting Point 233-235ºC
MSDS N/A Flash Point 253.7ºC

 Use of Quinine sulfate dihydrate


Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].

 Names

Name quinine sulfate dihydrate
Synonym More Synonyms

 Quinine sulfate dihydrate Biological Activity

Description Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].
Related Catalog
References

[1]. Shilu Malakar,et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25.  

[2]. Jhanwar, Deepika,et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate.(2016): 2636-2640.

[3]. Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23(1):39-44  

 Chemical & Physical Properties

Boiling Point 495.9ºC at 760 mmHg
Melting Point 233-235ºC
Molecular Formula C20H30N2O8S
Molecular Weight 458.53
Flash Point 253.7ºC
Exact Mass 782.356079
PSA 192.62000
LogP 6.52160

 MSDS

Name: Quinine sulfate dihydrate 99+% Material Safety Data Sheet
Synonym: Quinine sulfate; Quinine bisulfate; Quinine hydrogen sulfate
CAS: 6119-70-6
Section 1 - Chemical Product MSDS Name:Quinine sulfate dihydrate 99+% Material Safety Data Sheet
Synonym:Quinine sulfate; Quinine bisulfate; Quinine hydrogen sulfate

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
6119-70-6 Quinine sulfate dihydrate > 99 unlisted
Hazard Symbols: XN
Risk Phrases: 20/21/22

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed.Light sensitive.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin. May cause an allergic reaction in certain individuals.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause muscle tremor and impaired motor function. May cause systemic toxic effects on the heart, liver, and kidneys.
Exposure may cause anemia and other blood abnormalities. May cause nausea and vomiting. May cause acute hepatitis. May cause allergic reaction. Ingestion can cause blurred vision, narrowing of the visual field, or blindness.
Inhalation:
May cause respiratory tract irritation. May cause effects similar to those described for ingestion. Harmful if inhaled.
Chronic:
Prolonged or repeated skin contact may cause sensitization dermatitis and possible destruction and/or ulceration. Adverse reproductive effects have been reported in animals.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with skin and eyes. Keep container tightly closed. Do not ingest or inhale.
Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store protected from light.
Store in a cool, dry area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 6119-70-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white to off-white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 233.00 - 235.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: > 235 deg C
Solubility in water: 1 g/810 mL water (20C)
Specific Gravity/Density: Not available.
Molecular Formula: C40H48N4O4.H2SO4.2H2O
Molecular Weight: 782.96

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures. May decompose when exposed to light. Light sensitive.
Conditions to Avoid:
Light, dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents, direct light, ammonia, bases.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 6119-70-6 unlisted.
LD50/LC50:
Not available.
Oral, woman: LDLo = 220 mg/kg. Oral, rat: LDLo = 800 mg/kg.
Carcinogenicity:
Quinine sulfate dihydrate - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION
Other No information available.

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
Safety Phrases:
S 22 Do not breathe dust.
S 36 Wear suitable protective clothing.
WGK (Water Danger/Protection)
CAS# 6119-70-6: 2
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 6119-70-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 6119-70-6 is not on the TSCA Inventory because it is a hydrate.
It is considered to be listed if the CAS number for the anhydrous form
is on the inventory (40CFR720.3(u)(2)).


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xn:Harmful
Risk Phrases R22;R42/43
Safety Phrases S24-S37-S45
RIDADR UN 2811
WGK Germany 3
RTECS VA8440000
HS Code 29392000

 Customs

HS Code 29392000

 Synonyms

Hydrogen sulfate - (8α,9R)-6'-methoxycinchonan-9-ol hydrate (2:1:2:2)
Hydrogen sulfate (8α,9R)-6'-methoxycinchonan-9-ol hydrate (2:1:2:2)
EINECS 212-359-2
Quinine Sulfate Dihydrate
(5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol,sulfuric acid,dihydrate
Cinchonan-9-ol, 6'-methoxy-, (8α,9R)-, sulfate, hydrate (2:1:2) (salt)
MFCD00150790
Top Suppliers:I want be here





Get all suppliers and price by the below link:

Quinine sulfate dihydrate suppliers


Price: ¥106/5g

Reference only. check more Quinine sulfate dihydrate price