Piperacillin

Modify Date: 2024-01-05 16:30:47

Piperacillin Structure
Piperacillin structure
 Common Name Piperacillin
CAS Number 61477-96-1 Molecular Weight 517.555
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C23H27N5O7S Melting Point 139-140ºC
MSDS N/A Flash Point N/A

 Use of Piperacillin


Piperacillin is kind of semisynthetic penicillins. Piperacillin has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Piperacillin has shown greater activity against β-lactamase-producing organisms than the other penicillins[1].

 Names

Name piperacillin
Synonym More Synonyms

 Piperacillin Biological Activity

Description Piperacillin is kind of semisynthetic penicillins. Piperacillin has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Piperacillin has shown greater activity against β-lactamase-producing organisms than the other penicillins[1].
Related Catalog
References

[1]. B. Holmes, et al. A Review of its Antibacterial Activity, Pharmacokinetic Properties and Therapeutic Use.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Melting Point 139-140ºC
Molecular Formula C23H27N5O7S
Molecular Weight 517.555
Exact Mass 517.163147
PSA 181.73000
LogP 1.88
Index of Refraction 1.678
Storage condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH8952200
CHEMICAL NAME :
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-6-(((((4-ethyl-2,3-dioxo- 1-piperazinyl)carbonyl)amino)phenylacetyl)amino)-7-ox o-, (2S-(2-alpha,5-alpha,6-beta(S*)))-
CAS REGISTRY NUMBER :
61477-96-1
LAST UPDATED :
199706
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C23-H27-N5-O7-S
MOLECULAR WEIGHT :
517.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,987,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5651 No. of Facilities: 148 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 9665 (estimated) No. of Female Employees: 8470 (estimated)

 Safety Information

Hazard Codes Xi
Risk Phrases 42/43
Safety Phrases 36/37
HS Code 2941101900

 Customs

HS Code 2941101900

 Synonyms

Pipercillin
(2R,5R,6R)-6-{[(2R)-2-{[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
6-[[[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
PIPC
EINECS 262-811-8
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-
PIPERACILLIN SODIUM
PIPERACILLIN NA
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-, (2R,5R,6R)-
Piperacillin anhydrous
6-{[{[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino}(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
MFCD00917471
PIPERAILLIN
Pipracil
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Related Compounds: More...
Piperacillin
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piperacillin amide
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Piperacillin Impurity 4
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Piperacillin Impurity 3
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Piperacillin Impurity 5
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Piperacillin Impurity 7
63422-71-9
Piperacillin Impurity 2
64817-22-7
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