Tomatidine hydrochloride
Modify Date: 2026-07-02 08:57:29
Tomatidine hydrochloride structure
|
Common Name | Tomatidine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 6192-62-7 | Molecular Weight | 452.113 | |
| Density | N/A | Boiling Point | 551.1ºC at 760 mmHg | |
| Molecular Formula | C27H46ClNO2 | Melting Point | 281-284ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 287.1ºC | |
Use of Tomatidine hydrochlorideTomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. |
| Name | Tomatidin Hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. |
|---|---|
| Related Catalog | |
| Target |
p65 JNK |
| In Vitro | Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity[1]. |
| Cell Assay | RAW 264.7 cells, derived from murine macrophages, are cultured in DMEM supplemented with 10% endotoxin-free, heat-inactivated fetal calf serum, Penicillin (100 units/mL), and Streptomycin (100 μg/mL) in a 5% CO2 atmosphere at 37 °C in a humidified incubator. For all assay, cell is plated at 2×105 cells/cm2 in culture dishes or plates. Treatment with vehicle (0.1% DMSO or 0.1% ethanol), test compounds and/or LPS is carried out under serum-free conditions[1]. |
| References |
| Boiling Point | 551.1ºC at 760 mmHg |
|---|---|
| Melting Point | 281-284ºC (dec.) |
| Molecular Formula | C27H46ClNO2 |
| Molecular Weight | 452.113 |
| Flash Point | 287.1ºC |
| Exact Mass | 451.321716 |
| PSA | 41.49000 |
| LogP | 6.49760 |
| InChIKey | SXXHVPYRDFJKPG-XRWUXUKGSA-N |
| SMILES | CC1CCC2(NC1)OC1CC3C4CCC5CC(O)CCC5(C)C4CCC3(C)C1C2C.Cl |
| Storage condition | -20℃ |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
|
Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation.
Carcinogenesis 30 , 131-40, (2009) Aberrant activation of hedgehog (HH) pathway has been implicated in the development of human malignancies. This study aimed at investigating the role of HH molecules in human ovarian carcinogenesis. T... |
|
|
Activation of the hedgehog pathway in human hepatocellular carcinomas.
Carcinogenesis 27 , 1334-40, (2006) Liver cancers, the majority of which are hepatocellular carcinomas (HCCs), rank as the fourth in cancer mortality worldwide and are the most rapidly increasing type of cancer in the United States. How... |
|
Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
|
|
Name: qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signa...
Source: 824
Target: AR protein [Homo sapiens]
External Id: MDAN535
|
|
Name: Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL4296184
|
|
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
|
|
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
|
|
Name: Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ...
Source: ChEMBL
Target: Klebsiella pneumoniae
External Id: CHEMBL4296186
|
|
Name: qHTS assay to identify small molecule antagonists of the androgen receptor (AR) sign...
Source: 824
Target: N/A
External Id: MDAV150
|
|
Name: Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL4296185
|
|
Name: qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cel...
Source: 824
Target: RecName: Full=ATPase family AAA domain-containing protein 5; AltName: Full=Chromosome fragility-associated gene 1 protein
External Id: ELG271
|
|
Name: qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signal...
Source: 824
Target: thyroid hormone receptor beta isoform 2 [Rattus norvegicus]
External Id: TRN186
|
Total 80, Current Page 1 of 8
1
2
3
4
5
| MFCD00133866 |
| (3β,5α,25S)-Spirosolan-3-ol hydrochloride (1:1) |
| Spirosolan-3-ol, (3β,5α,25S)-, hydrochloride (1:1) |
| Tomatidine hydrochloride |