N-Nitrosodimethylamine
N-Nitrosodimethylamine structure
|
Common Name | N-Nitrosodimethylamine | ||
|---|---|---|---|---|
| CAS Number | 62-75-9 | Molecular Weight | 74.082 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 152.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C2H6N2O | Melting Point | 50ºC | |
| MSDS | Chinese USA | Flash Point | 36.1±18.7 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
Use of N-NitrosodimethylamineDimethylnitrosamine (NDMA) is a potent hepatotoxin, carcinogen and mutagen. Dimethylnitrosamine can be used to induces liver tumors[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | N,N-dimethylnitrous amide |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Dimethylnitrosamine (NDMA) is a potent hepatotoxin, carcinogen and mutagen. Dimethylnitrosamine can be used to induces liver tumors[1][2]. |
|---|---|
| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 152.0±0.0 °C at 760 mmHg |
| Melting Point | 50ºC |
| Molecular Formula | C2H6N2O |
| Molecular Weight | 74.082 |
| Flash Point | 36.1±18.7 °C |
| Exact Mass | 74.048012 |
| PSA | 32.67000 |
| LogP | -0.64 |
| Vapour Pressure | 4.6±0.2 mmHg at 25°C |
| Index of Refraction | 1.427 |
| InChIKey | UMFJAHHVKNCGLG-UHFFFAOYSA-N |
| SMILES | CN(C)N=O |
| Stability | Stability Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases, strong reducing agents. |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H350-H370 |
| Precautionary Statements | P201-P210-P260-P280-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | T+,N,T,F |
| Risk Phrases | 45-25-26-48/25-51/53-39/23/24/25-23/24/25-11 |
| Safety Phrases | S53-S45-S61-S36/37 |
| RIDADR | UN 3382 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | IQ0525000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 8 | |
|---|---|
| DownStream 10 | |
CAS#:124-40-3
CAS#:51-80-9
CAS#:111-18-2
CAS#:110-95-2
CAS#:111-51-3
CAS#:57-14-7
CAS#:67-68-5
CAS#:75-50-3
CAS#:333-27-7
CAS#:593-82-8
CAS#:75-17-2
CAS#:1761-67-7
CAS#:75-58-1
CAS#:13256-12-7
CAS#:10595-95-6
CAS#:50-00-0This table lists relevant public references with title, journal and publication metadata for this compound.
|
[Effect of cordyceps polysaccharide on lipid peroxidation of rats with dimethylnitrosamine-induced liver fibrosis].
Zhongguo Zhong Yao Za Zhi 38(3) , 391-6, (2013) To observe the pharmacological effect of Cordyceps polysaccharide on dimethylnitrosamine (DMN)-induced liver fibrosis in rats.DMN rat liver fibrosis model was established and divided into the normal g... |
|
|
Relationship between organic precursors and N-nitrosodimethylamine (NDMA) formation in tropical water sources.
J. Water Health 12(4) , 736-46, (2014) The presence of organic compounds in water sources is one of the concerns in water treatment. They are potential precursors of disinfection byproducts (DBPs) and thus induce health problems in humans.... |
|
|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
|
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
|
|
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
|
|
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
|
|
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
|
|
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482
|
|
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| N-NITROSODIMETHYLAMINE |
| dimethyl-nitrosoamine |
| EINECS 200-549-8 |
| N-Methyl-N-nitrosomethanamine |
| MFCD00002053 |
| Methanamine,N-methyl-N-nitroso |
| Dimethylnitrosamine |
| Nitrosodimethylamine |
| DMNA |
| [14C]-Dimethylnitrosamine |
| N,N-Dimethylnitrosamine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the boiling point of N,N-dimethylnitrous amide? |
| A: Boiling point of N,N-dimethylnitrous amide is 152.0±0.0 °C at 760 mmHg. |
| Q: What are the downstream products of N,N-dimethylnitrous amide? |
| A: Related downstream products(CAS) of N,N-dimethylnitrous amide: 333-27-7;593-82-8;75-17-2;1761-67-7;57-14-7;124-40-3;75-58-1;13256-12-7;10595-95-6;50-00-0. |
| Q: What is the SMILES notation of N,N-dimethylnitrous amide? |
| A: SMILES notation of N,N-dimethylnitrous amide is CN(C)N=O. |
| Q: What is the LogP of N,N-dimethylnitrous amide? |
| A: LogP of N,N-dimethylnitrous amide is -0.64. |
| Q: What is the polar surface area (PSA) of N,N-dimethylnitrous amide? |
| A: Polar surface area (PSA) of N,N-dimethylnitrous amide is 32.67000. |
| Q: What is the molecular weight of N,N-dimethylnitrous amide? |
| A: Molecular weight of N,N-dimethylnitrous amide is 74.082. |
| Q: What are the upstream materials of N,N-dimethylnitrous amide? |
| A: Related upstream materials(CAS) of N,N-dimethylnitrous amide: 124-40-3;51-80-9;111-18-2;110-95-2;111-51-3;57-14-7;67-68-5;75-50-3. |
| Q: What English synonyms does N,N-dimethylnitrous amide have? |
| A: English synonyms of N,N-dimethylnitrous amide: N-NITROSODIMETHYLAMINE, dimethyl-nitrosoamine, EINECS 200-549-8, N-Methyl-N-nitrosomethanamine, MFCD00002053, Methanamine,N-methyl-N-nitroso, Dimethylnitrosamine, Nitrosodimethylamine, DMNA, [14C]-Dimethylnitrosamine, N,N-Dimethylnitrosamine. |
| Q: What is the CAS number of N,N-dimethylnitrous amide? |
| A: CAS number of N,N-dimethylnitrous amide is 62-75-9. |
| Q: What is the English name of N,N-dimethylnitrous amide? |
| A: The English name of N,N-dimethylnitrous amide is N,N-dimethylnitrous amide. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |