1,3,5-Trimethoxybenzene

Modify Date: 2025-08-19 22:40:36

1,3,5-Trimethoxybenzene structure	Common Name	1,3,5-Trimethoxybenzene
	CAS Number	621-23-8	Molecular Weight	168.190
	Density	1.0±0.1 g/cm3	Boiling Point	257.0±20.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₂O₃	Melting Point	50-53 °C(lit.)
	MSDS	Chinese USA	Flash Point	85.6±0.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of 1,3,5-Trimethoxybenzene

1,3,5-Trimethoxybenzene is a key component of the Chinese rose odor. 1,3,5-Trimethoxybenzene is synthesized in three successive methylation steps from phloroglucinol, the initial precursor. 1,3,5-Trimethoxybenzene is an effective sedative[1].

Name	1,3,5-trimethoxybenzene
Synonym	More Synonyms

Description	1,3,5-Trimethoxybenzene is a key component of the Chinese rose odor. 1,3,5-Trimethoxybenzene is synthesized in three successive methylation steps from phloroglucinol, the initial precursor. 1,3,5-Trimethoxybenzene is an effective sedative[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Wu S, et al. The key role of phloroglucinol O-methyltransferase in the biosynthesis of Rosa chinensis volatile 1,3,5-trimethoxybenzene. Plant Physiol. 2004 May;135(1):95-102.

Density	1.0±0.1 g/cm3
Boiling Point	257.0±20.0 °C at 760 mmHg
Melting Point	50-53 °C(lit.)
Molecular Formula	C₉H₁₂O₃
Molecular Weight	168.190
Flash Point	85.6±0.0 °C
Exact Mass	168.078644
PSA	27.69000
LogP	1.61
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.485
InChIKey	LKUDPHPHKOZXCD-UHFFFAOYSA-N
SMILES	COc1cc(OC)cc(OC)c1
Water Solubility	insoluble

1,3,5-Trimethoxybenzene MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC2810000

CHEMICAL NAME :: Benzene, 1,3,5-trimethoxy-

CAS REGISTRY NUMBER :: 621-23-8

BEILSTEIN REFERENCE NO. :: 1307993

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H12-O3

MOLECULAR WEIGHT :: 168.21

WISWESSER LINE NOTATION :: 1OR CO1 EO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,187,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 580 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,187,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,187,1969

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S24/25
RIDADR	1325
WGK Germany	3
RTECS	DC2810000
Packaging Group	III
Hazard Class	4.1
HS Code	29093090

Precursor 10
CAS#:626-39-1 1,3,5-Tribromob... CAS#:108-73-6 Phloroglucinol CAS#:77-78-1 Dimethyl sulfate CAS#:570-02-5 2,4,6-Trimethox...
CAS#:100-39-0 Benzyl bromide CAS#:135159-25-0 2,4,6-TRIMETHOX... CAS#:141-32-2 butyl acrylate CAS#:36086-05-2 trimethyl-(2,4,...
CAS#:124-41-4 Sodium Methylate CAS#:117934-81-3 2,4-diiodo-1,3,...
DownStream 10
CAS#:3420-72-2 Flavokawain A CAS#:491-70-3 Luteolin CAS#:14262-07-8 1,3,5-trimethox... CAS#:1219118-19-0 2-hydroxy-2',3,...
CAS#:15222-53-4 9H-Xanthen-9-on... CAS#:5128-44-9 7,4'-Di-O-methy... CAS#:3770-80-7 phenyl-(2,4,6-t... CAS#:493-77-6 s-Triazine, 2,4...
CAS#:90-24-4 Xanthoxylin CAS#:500-99-2 3,5-Dimethoxyphenol

HS Code	2909309090
Summary	2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

A denuder-impinger system with in situ derivatization followed by gas chromatography-mass spectrometry for the determination of gaseous iodine-containing halogen species.

J. Chromatogr. A. 1210(2) , 135-41, (2008)

Reactive iodine species have been suggested to play an important role in the atmosphere (e.g. tropospheric ozone depletion, coastal new particle formation). However, there still exist major uncertaint...

Ozonolysis of lignin models in aqueous solution: anisole, 1,2-dimethoxybenzene, 1,4-dimethoxybenzene, and 1,3,5-trimethoxybenzene.

Environ. Sci. Technol. 43(16) , 6275-82, (2009)

The lignin models anisole, 1,2-dimethoxybenzene, 1,4-dimethoxybenzene, and 1,3,5-trimethoxybenzene were reacted with ozone in aqueous solution, and major products were identified and quantified with r...

Stereoselective glycosylations using oxathiane spiroketal glycosyl donors.

Carbohydr. Res. 348 , 6-13, (2012)

Novel oxathiane spiroketal donors have been synthesised and activated via an umpolung S-arylation strategy using 1,3,5-trimethoxybenzene and 1,3-dimethoxybenzene. The comparative reactivity of the res...

Benzene,1,3,5-trimethoxy

1,3,5-trimethoxy-benzene

Benzene, 1,3,5-trimethoxy-

1,3,5-Trimethoxybenzene

tri-O-methylphloroglucinol

phloroglucinol trimethyl ether

2,4,6-Trimethoxybenzene

1,3,5-Trimethyoxybenzene

1,3,5-trimethoxy-benzen

sym-Trimethoxybenzene

2,4,6-trimethoxyiodobenzene

1,3,5-Trimethoxybenz

1,3,5-trimethoxyarene

MFCD00008385

5-TriMethoxybenzene

TRISMETHOXYBENZENE

3,5-DIMETHOXYANISOLE

EINECS 210-673-4

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China
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China
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Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 1,3,5-Trimethoxybenzene
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
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1,3,5-Trimethoxybenzene

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