Diethylene Glycol Monobenzyl Ether

Modify Date: 2024-01-02 05:47:51

Diethylene Glycol Monobenzyl Ether Structure
Diethylene Glycol Monobenzyl Ether structure
Common Name Diethylene Glycol Monobenzyl Ether
CAS Number 2050-25-1 Molecular Weight 196.243
Density 1.1±0.1 g/cm3 Boiling Point 311.2±22.0 °C at 760 mmHg
Molecular Formula C11H16O3 Melting Point N/A
MSDS Chinese USA Flash Point 142.0±22.3 °C

 Use of Diethylene Glycol Monobenzyl Ether


Diethylene Glycol Monobenzyl Ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-(2-phenylmethoxyethoxy)ethanol
Synonym More Synonyms

 Diethylene Glycol Monobenzyl Ether Biological Activity

Description Diethylene Glycol Monobenzyl Ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 311.2±22.0 °C at 760 mmHg
Molecular Formula C11H16O3
Molecular Weight 196.243
Flash Point 142.0±22.3 °C
Exact Mass 196.109940
PSA 38.69000
LogP 0.90
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.513

 Safety Information

Personal Protective Equipment Eyeshields;Gloves
RIDADR NONH for all modes of transport
HS Code 2909499000

 Synthetic Route

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles1

More Articles
Synthesis and characterization of star poly(epsilon-caprolactone)-b-poly(ethylene glycol) and poly(L-lactide)-b-poly(ethylene glycol) copolymers: evaluation as drug delivery carriers.

Bioconjug. Chem. 19(7) , 1423-9, (2008)

Two types of 32 arm star polymers incorporating amphiphilic block copolymer arms have been synthesized and characterized. The first type, stPCL-PEG 32, is composed of a polyamidoamine (PAMAM) dendrime...

 Synonyms

Ethanol, 2-[2-(phenylmethoxy)ethoxy]-
2-[2-(Benzyloxy)ethoxy]ethanol
Ethanol, 2-[2-(benzyloxy)ethoxy]-
Ethanol, 2-[2- (phenylmethoxy)ethoxy]-
Diethylene Glycol Monobenzyl Ether
MFCD00029649
Ethanol, 2-[2- (benzyloxy)ethoxy]-