n-Octacosane

Modify Date: 2024-01-02 08:29:52

n-Octacosane Structure
n-Octacosane structure
Common Name n-Octacosane
CAS Number 630-02-4 Molecular Weight 394.76000
Density N/A Boiling Point 278 °C15 mm Hg(lit.)
Molecular Formula C28H58 Melting Point 57-62 °C(lit.)
MSDS Chinese USA Flash Point 227 °C

 Use of n-Octacosane


Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[1][2][3].

 Names

Name octacosane
Synonym More Synonyms

 n-Octacosane Biological Activity

Description Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[1][2][3].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro 二十八烷 (12.5-100 μg/ml; 18 小时) 对 B16F10-Nex2 细胞具有很强的细胞毒活性,IC50 值为 41.08 μg/ml[1]。 Cell Cytotoxicity Assay[1] Cell Line: B16F10-Nex2 cells Concentration: 12.5, 25, 50, 100 μg/ml Incubation Time: 18 h Result: Displayed strong cytotoxic activity on B16F10-Nex2 cells, with an IC50 value of 41.08 μg/ml
In Vivo 二十八烷 (500 μg; 在与原始细胞移植相关的外周部位注射; 每天; 35 天) 可显着延缓肿瘤进展,并具有显着的抗肿瘤作用[1]。 Animal Model: C57Bl/6 mice with B16F10-Nex2 Cellsl[1] Dosage: 500 μg Administration: Injected at peripheral sites in relation to the original cell grafting; daily; 35 days Result: Resulted in a significant delay of tumor progression with a significant antitumor effect. The survival rate of treated groups was significantly increased.
References

[1]. Carlos R Figueiredo, et al. Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo. Pharmacogn Mag. 2014 Apr;10(Suppl 2):S363-76.  

[2]. S Rajkumar, et al. Mosquitocidal activities of octacosane from Moschosma polystachyum Linn (lamiaceae). J Ethnopharmacol. 2004 Jan;90(1):87-9.  

[3]. Sameh S M Soliman, et al. Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites. PLoS One. 2020 Oct 6;15(10):e0240156.  

 Chemical & Physical Properties

Boiling Point 278 °C15 mm Hg(lit.)
Melting Point 57-62 °C(lit.)
Molecular Formula C28H58
Molecular Weight 394.76000
Flash Point 227 °C
Exact Mass 394.45400
LogP 11.16880
Vapour density 13.6 (vs air)
Vapour Pressure <1 mm Hg ( 20 °C)
Index of Refraction 1.4330 (70ºC)
Stability Stable. Combustible. Incompatible with strong oxidizing agents.

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
Packaging Group II; III
Hazard Class 4.1
HS Code 29011090

 Synthetic Route

 Customs

HS Code 29011090

 Articles8

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The aerial parts of all land plants are covered with hydrophobic cuticular wax layers that act as the first barrier against the environment. The MYB94 transcription factor gene is expressed in abundan...

Uptake and utilization of n-octacosane and n-nonacosane by Arthrobacter nicotianae KCC B35.

J. Appl. Bacteriol. 80(4) , 370-4, (1996)

Arthrobacter nicotianae KCC B35 isolated from blue-green mats densely covering oil sediments along the Arabian Gulf coast grew well on C10 to C40 n-alkanes as sole sources of carbon and energy. Growth...

[Chemical constituents of Astragalus chinensis L].

Zhongguo Zhong Yao Za Zhi 20(5) , 296-7, 320, (1995)

Three compounds have been isolated from the seeds of Astragalus chinensis. Their structures were identified on the basis of spectral data (UV, 13CNMR, 1HNMR, IR and MS) as octacosane, daucosterol and ...

 Synonyms

N-o-Carbomethoxyphenyl-N'-phenylthiourea
Benzoic acid,2-[[(phenylamino)thioxomethyl]amino]-,methyl ester
EINECS 211-125-7
MFCD00009355
n-Octakosan
n-Octacosane
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