BULBOCAPNINE HYDROCHLORIDE

Modify Date: 2024-01-10 19:05:08

BULBOCAPNINE HYDROCHLORIDE structure	Common Name	BULBOCAPNINE HYDROCHLORIDE
	CAS Number	632-47-3	Molecular Weight	361.82
	Density	N/A	Boiling Point	504ºC at 760 mmHg
	Molecular Formula	C₁₉H₂₀ClNO₄	Melting Point	209-210ºC
	MSDS	USA	Flash Point	258.6ºC
	Symbol	GHS07	Signal Word	Warning

Use of BULBOCAPNINE HYDROCHLORIDE

Bulbocapnine hydrochloride, an aporphine alkaloid, is a dopamine receptor inhibitor. Bulbocapnine hydrochloride inhibits dopamine synthesis. Bulbocapnine hydrochloride also has neuroleptic-like, anticonvulsant and antinociceptive effects[1][2][3].

Name	bulbocapnine hydrochloride
Synonym	More Synonyms

Description	Bulbocapnine hydrochloride, an aporphine alkaloid, is a dopamine receptor inhibitor. Bulbocapnine hydrochloride inhibits dopamine synthesis. Bulbocapnine hydrochloride also has neuroleptic-like, anticonvulsant and antinociceptive effects[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
References	[1]. Shin JS, et al. Inhibitory effects of bulbocapnine on dopamine biosynthesis in PC12 cells. Neurosci Lett. 1998 Mar 20;244(3):161-4. [2]. Zetler G. Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: bulbocapnine, corytuberine, boldine and glaucine. Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:255-81. [3]. Kohli JD,et al. Bulbocapnine is not a selective DA1 receptor antagonist. J Pharm Pharmacol. 1986 May;38(5):401-2.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

References

[1]. Shin JS, et al. Inhibitory effects of bulbocapnine on dopamine biosynthesis in PC12 cells. Neurosci Lett. 1998 Mar 20;244(3):161-4.

[2]. Zetler G. Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: bulbocapnine, corytuberine, boldine and glaucine. Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:255-81.

[3]. Kohli JD,et al. Bulbocapnine is not a selective DA1 receptor antagonist. J Pharm Pharmacol. 1986 May;38(5):401-2.

Boiling Point	504ºC at 760 mmHg
Melting Point	209-210ºC
Molecular Formula	C₁₉H₂₀ClNO₄
Molecular Weight	361.82
Flash Point	258.6ºC
Exact Mass	361.10800
PSA	51.16000
LogP	3.62150
Appearance of Characters	solid \| tan
Storage condition	2-8°C

BULBOCAPNINE HYDROCHLORIDE MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CE1054000

CHEMICAL NAME :: 6a-alpha-Aporphin-11-ol, 10-methoxy-1,2-(methylenedioxy)-, hydrochloride

CAS REGISTRY NUMBER :: 632-47-3

LAST UPDATED :: 199012

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H19-N-O4.Cl-H

MOLECULAR WEIGHT :: 361.85

WISWESSER LINE NOTATION :: T D56 J666 1A T EO GO RN FH&&&TTJ KQ LO1 R1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 236,149,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 31,27,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 137,375,1962

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CE1054000

N-METHYLLAUNOBINE HYDROCHLORIDE

MFCD00069363

EINECS 211-178-6

BULBOCAPNINE HCL

Buibocapnine hydrochloride

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinolin-12-ol,6,7,7a,8-tetrahydro-11-methoxy-7-methyl-, hydrochloride, (7aS)- (9CI)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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