1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol

Modify Date: 2024-01-03 12:04:47

1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol Structure
1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol structure
Common Name 1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol
CAS Number 5306-85-4 Molecular Weight 174.19
Density 1.2±0.1 g/cm3 Boiling Point 236.4±40.0 °C at 760 mmHg
Molecular Formula C8H14O4 Melting Point -70°C
MSDS N/A Flash Point 108.3±0.0 °C

 Use of 1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol


Isosorbide dimethyl ether is a biobased high boiling green solvent. Isosorbide dimethyl ether can be used for sustainable ultrafiltration and microfiltration membrane preparation. Isosorbide dimethyl ether can be used as an excipient, such as solvent, penetration aid. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

 Names

Name Isosorbide Dimethyl Ether
Synonym More Synonyms

  Biological Activity

Description Isosorbide dimethyl ether is a biobased high boiling green solvent. Isosorbide dimethyl ether can be used for sustainable ultrafiltration and microfiltration membrane preparation. Isosorbide dimethyl ether can be used as an excipient, such as solvent, penetration aid. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. Russo F, et al. Dimethyl isosorbide as a green solvent for sustainable ultrafiltration and microfiltration membrane preparation[J]. ACS Sustainable Chemistry & Engineering, 2019, 8(1): 659-668.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 236.4±40.0 °C at 760 mmHg
Melting Point -70°C
Molecular Formula C8H14O4
Molecular Weight 174.19
Flash Point 108.3±0.0 °C
Exact Mass 174.089203
PSA 36.92000
LogP -0.65
Vapour Pressure 0.1±0.5 mmHg at 25°C
Index of Refraction 1.466

 Safety Information

Safety Phrases S23-S24/25
WGK Germany 3
HS Code 2932999099

 Synthetic Route

~95%

1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol Structure

1,4:3,6-Dianhyd...

CAS#:5306-85-4

Literature: Tundo, Pietro; Arico, Fabio; Gauthier, Guillaume; Rossi, Laura; Rosamilia, Anthony E.; Bevinakatti, Hanamanthsa S.; Sievert, Robert L.; Newman, Christoper P. ChemSusChem, 2010 , vol. 3, # 5 p. 566 - 570

~32%

Detail
Literature: Tundo, Pietro; Arico, Fabio; Gauthier, Guillaume; Rossi, Laura; Rosamilia, Anthony E.; Bevinakatti, Hanamanthsa S.; Sievert, Robert L.; Newman, Christoper P. ChemSusChem, 2010 , vol. 3, # 5 p. 566 - 570

~%

Detail
Literature: ChemSusChem, , vol. 3, # 5 p. 566 - 570

~19%

Detail
Literature: ChemSusChem, , vol. 3, # 5 p. 566 - 570

~%

1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol Structure

1,4:3,6-Dianhyd...

CAS#:5306-85-4

Literature: Journal of the Chemical Society, , p. 390,392

~%

1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol Structure

1,4:3,6-Dianhyd...

CAS#:5306-85-4

Literature: Journal of the Chemical Society, , p. 390,392

~%

1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol Structure

1,4:3,6-Dianhyd...

CAS#:5306-85-4

Literature: Journal of the Chemical Society, , p. 390,392

~%

1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol Structure

1,4:3,6-Dianhyd...

CAS#:5306-85-4

Literature: Journal of the Chemical Society, , p. 390,392

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

D-Glucitol, 1,4:3,6-dianhydro-2,5-di-O-methyl-
MFCD00064828
EINECS 226-159-8
(3S,3aR,6R,6aR)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan
Glucitol, 1,4:3,6-dianhydro-2,5-di-O-methyl-, D-
Isosorbide DiMethyl Ether
D-Glucitol, 1,4:3,6-dianhydro-2,5-di-O-methyl
1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol
(3R,3aR,6S,6aR)-3,6-Dimethoxyhexahydrofuro[3,2-b]furan
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