Ranitidine hydrochloride structure
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Common Name | Ranitidine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 66357-59-3 | Molecular Weight | 350.865 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H23ClN4O3S | Melting Point | 134°C (dec.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of Ranitidine hydrochlorideRanitidine is a histamine H2-receptor antagonist that inhibits stomach acid production. Target: Histamine H2-ReceptorRanitidine (Zantac) is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 uM. It inhibits stomach acid production. It is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. It has 10% the affinity that cimetidine has to CYP450 so it causes fewer side effects, but other H2 blockers famotidine and nizatidine have no CYP450 significant interactions [1, 2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | ranitidine hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Ranitidine is a histamine H2-receptor antagonist that inhibits stomach acid production. Target: Histamine H2-ReceptorRanitidine (Zantac) is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 uM. It inhibits stomach acid production. It is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. It has 10% the affinity that cimetidine has to CYP450 so it causes fewer side effects, but other H2 blockers famotidine and nizatidine have no CYP450 significant interactions [1, 2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Melting Point | 134°C (dec.) |
|---|---|
| Molecular Formula | C13H23ClN4O3S |
| Molecular Weight | 350.865 |
| Exact Mass | 350.117950 |
| PSA | 111.56000 |
| LogP | 3.56600 |
| Storage condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Water Solubility | H2O: 1.8 mg/mL |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | F,T |
| Risk Phrases | R20/21/22 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | KM6557000 |
| HS Code | 2933990090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Ranitidine hydr... CAS#:66357-59-3 |
| Literature: US2006/205944 A1, ; Page/Page column 3 ; |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 1 | |
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| DownStream 0 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Histamine inhibits differentiation of skin fibroblasts into myofibroblasts.
Biochem. Biophys. Res. Commun. 463 , 434-9, (2015) Histamine and TGF-β, major mediators secreted by mast cells, are involved in skin inflammation and play critical roles in the pathogenesis of systemic sclerosis. However, the roles of signaling mechan... |
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Involvement of histaminergic inputs in the jaw-closing reflex arc.
J. Neurophysiol. 113 , 3720-35, (2015) Histamine receptors are densely expressed in the mesencephalic trigeminal nucleus (MesV) and trigeminal motor nucleus. However, little is known about the functional roles of neuronal histamine in cont... |
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Uptake and effects of a mixture of widely used therapeutic drugs in Eruca sativa L. and Zea mays L. plants.
Ecotoxicol. Environ. Saf. 108 , 52-7, (2014) Pharmaceutically active compounds (PACs) are continuously dispersed into the environment due to human and veterinary use, giving rise to their potential accumulation in edible plants. In this study, E... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Sostril |
| Terposen |
| Raniben |
| Ultidine |
| 1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-, hydrochloride (1:1) |
| Ranitidine HCl salt |
| Noctone |
| Taural |
| Zantac |
| Trigger |
| UNII-BK76465IHM |
| Raniplex |
| Ranidil |
| Zantic |
| Ranitidine hydrochloride |
| EINECS 266-332-5 |
| MFCD00069339 |
| Azantac |
| N-{2-[({5-[(Dimethylamino)methyl]-2-furyl}methyl)sulfanyl]ethyl}-N'-methyl-2-nitro-1,1-ethenediamine hydrochloride (1:1) |
| Ulcex |
| Ranitidine HCl |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of ranitidine hydrochloride? |
| A: CAS number of ranitidine hydrochloride is 66357-59-3. |
| Q: What is the molecular weight of ranitidine hydrochloride? |
| A: Molecular weight of ranitidine hydrochloride is 350.865. |
| Q: What is the polar surface area (PSA) of ranitidine hydrochloride? |
| A: Polar surface area (PSA) of ranitidine hydrochloride is 111.56000. |
| Q: What is the LogP of ranitidine hydrochloride? |
| A: LogP of ranitidine hydrochloride is 3.56600. |
| Q: What is the molecular formula of ranitidine hydrochloride? |
| A: Molecular formula of ranitidine hydrochloride is C13H23ClN4O3S. |
| Q: What is the English name of ranitidine hydrochloride? |
| A: The English name of ranitidine hydrochloride is ranitidine hydrochloride. |
| Q: What are the storage conditions for ranitidine hydrochloride? |
| A: Storage conditions for ranitidine hydrochloride: Hygroscopic, -20°C Freezer, Under Inert Atmosphere. |
| Q: What is the safety information for ranitidine hydrochloride? |
| A: Safety information for ranitidine hydrochloride: S22-S24/25. |
| Q: How is the water solubility of ranitidine hydrochloride? |
| A: Water solubility of ranitidine hydrochloride: H2O: 1.8 mg/mL. |
| Q: What is the melting point of ranitidine hydrochloride? |
| A: Melting point of ranitidine hydrochloride is 134°C (dec.). |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |