Ratic

Modify Date: 2026-07-02 16:30:16

Ratic structure	Common Name	Ratic
	CAS Number	66357-35-5	Molecular Weight	314.404
	Density	1.2±0.1 g/cm3	Boiling Point	437.1±45.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₂₂N₄O₃S	Melting Point	69-70°C
	MSDS	N/A	Flash Point	218.2±28.7 °C

Use of Ratic

Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine is a weak inhibitor of CYP2C19 and CYP2C9[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	ranitidine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine is a weak inhibitor of CYP2C19 and CYP2C9[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Anti-infection >> Bacterial
Target	H2 Receptor:3.3 μM (IC50) CYP2C19 CYP2C9
References	[1]. A W Herling, et al. Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions. 1987 Feb;20(1-2):35-9. [2]. A Leucuta, et al. A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact. 2004;20(4):273-81. [3]. Antonio Francesco Ciccaglione, et al. Pylera® plus ranitidine vs Pylera® plus esomeprazole in first-line treatment of Helicobacter pylori infection: Two pilot studies. Helicobacter. 2019 Oct;24(5):e12606.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.2±0.1 g/cm3
Boiling Point	437.1±45.0 °C at 760 mmHg
Melting Point	69-70°C
Molecular Formula	C₁₃H₂₂N₄O₃S
Molecular Weight	314.404
Flash Point	218.2±28.7 °C
Exact Mass	314.141266
PSA	111.56000
LogP	1.23
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.559
Storage condition	Desiccate at +4°C
Water Solubility	24.7 mg/mL

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM6556500

CHEMICAL NAME :: 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)th io)ethyl)-N'-methyl- 2-nitro-

CAS REGISTRY NUMBER :: 66357-35-5

LAST UPDATED :: 199703

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C13-H22-N4-O3-S

MOLECULAR WEIGHT :: 314.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 12 mg/kg/2D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - interstitial nephritis Blood - other changes Skin and Appendages - dermatitis, allergic (after topical exposure)

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 12,67,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 93 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2018 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 884 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 25,749,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Safety Phrases	S22-S24/25
WGK Germany	2
RTECS	KM6557000
HS Code	2932999099

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 5
CAS#:66356-53-4 2-[([5-[(Dimeth... CAS#:7440-44-0 Carbon CAS#:13623-94-4 1-nitro-2,2-bis... CAS#:66357-07-1 N-methyl-N'-(2-...
CAS#:75-52-5 nitromethane
DownStream 5
CAS#:66357-59-3 Ranitidine hydr... CAS#:15433-79-1 [5-[(dimethylam... CAS#:112233-24-6 (6Z)-6-[[5-[(di... CAS#:112233-23-5 5,6-Dihydro-3-(...
CAS#:112233-25-7 N,N-dimethyl-5-...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Taural

Sostril

Terposen

Trigger

U1tidine

Ranitidine

Zantic

MFCD00081180

RANITIDINE USP

EINECS 266-332-5

U1cex

Zantae

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: How is the water solubility of ranitidine?

A: Water solubility of ranitidine: 24.7 mg/mL.

Q: What English synonyms does ranitidine have?

A: English synonyms of ranitidine: Taural, Sostril, Terposen, Trigger, U1tidine, Ranitidine, Zantic, MFCD00081180, RANITIDINE USP, EINECS 266-332-5, U1cex, Zantae.

Q: What is the LogP of ranitidine?

A: LogP of ranitidine is 1.23.

Q: What is the molecular formula of ranitidine?

A: Molecular formula of ranitidine is C13H22N4O3S.

Q: What is the English name of ranitidine?

A: The English name of ranitidine is ranitidine.

Q: What are the uses of ranitidine?

A: Main uses of ranitidine: Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine is a weak inhibitor of CYP2C19 and CYP2C9[1][2].

Q: What is the CAS number of ranitidine?

A: CAS number of ranitidine is 66357-35-5.

Q: What is the polar surface area (PSA) of ranitidine?

A: Polar surface area (PSA) of ranitidine is 111.56000.

Q: What is the safety information for ranitidine?

A: Safety information for ranitidine: S22-S24/25.

Q: What is the boiling point of ranitidine?

A: Boiling point of ranitidine is 437.1±45.0 °C at 760 mmHg.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ratic
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Ranitidine hydrochloride HCL form II USP
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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