Ethyl [(4-methylphenyl)sulfonyl]carbamate

Modify Date: 2025-08-21 18:28:14

Ethyl [(4-methylphenyl)sulfonyl]carbamate structure	Common Name	Ethyl [(4-methylphenyl)sulfonyl]carbamate
	CAS Number	5577-13-9	Molecular Weight	243.279
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₃NO₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ethyl [(4-methylphenyl)sulfonyl]carbamate

Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].

Name	Ethyl N-(4-methylphenyl)sulfonylcarbamate
Synonym	More Synonyms

Description	Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27(4):301-27. [2]. Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57(13), 1476–1478. [3]. Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55(6): p. 722-30.

Description

Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].

Related Catalog

Research Areas >> Metabolic Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

References

[1]. Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27(4):301-27.

[2]. Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57(13), 1476–1478.

[3]. Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55(6): p. 722-30.

Density	1.3±0.1 g/cm3
Molecular Formula	C₁₀H₁₃NO₄S
Molecular Weight	243.279
Exact Mass	243.056534
PSA	80.85000
LogP	1.86
Index of Refraction	1.530

Hazard Codes	Xi
HS Code	2935009090

Ethyl chloroformate

CAS#:541-41-3

4-Toluenesulfonamide

CAS#:70-55-3

~88%

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: Xi, Pin-xian; Xu, Zhi-hong; Liu, Xiao-hui; Cheng, Feng-juan; Zeng, Zheng-zhi Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 71, # 2 p. 523 - 528 Title/Abstract Full Text View citing articles Show Details Xi, Pin-Xian; Xu, Zhi-Hong; Liu, Xiao-Hui; Chen, Feng-Juan; Huang, Liang; Zeng, Zheng-Zhi Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 541 - 546

p-Toluenesulfon...

CAS#:4083-64-1

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: US5326796 A1, ;

1,3-bis-(4-meth...

CAS#:5219-81-8

Ethyl carbonate

CAS#:105-58-8

~91%

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: Guo, Xiaoguang; Shang, Jianpeng; Li, Jian; Wang, Liguo; Ma, Yubo; Shi, Feng; Deng, Youquan Synthetic Communications, 2011 , vol. 41, # 8 p. 1102 - 1111

4-Toluenesulfonamide

CAS#:70-55-3

Hexamethylphosp...

CAS#:1608-26-0

~33%

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: Bittner, Shmuel; Assaf, Yonit; Krief, Penina; Pomerantz, Martin; Ziemnicka, Barbara T.; Smith, Christina G. Journal of Organic Chemistry, 1985 , vol. 50, # 10 p. 1712 - 1718

P-TOLUENESULFIN...

CAS#:10439-23-3

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 31, p. 2381 - 2385,2218 - 2222

p-Toluol-(-N-ca...

CAS#:93506-31-1

Ethyl [(4-methy...

CAS#:5577-13-9

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 31, p. 2381 - 2385,2218 - 2222

Precursor 7
CAS#:541-41-3 Ethyl chloroformate CAS#:70-55-3 4-Toluenesulfonamide CAS#:4083-64-1 p-Toluenesulfon... CAS#:5219-81-8 1,3-bis-(4-meth...
CAS#:105-58-8 Ethyl carbonate CAS#:1608-26-0 Hexamethylphosp... CAS#:10439-23-3 P-TOLUENESULFIN...
DownStream 7
CAS#:4083-64-1 p-Toluenesulfon... CAS#:28490-28-0 3-Pentenamide,4... CAS#:28490-61-1 2-Butenamide,3-... CAS#:28490-23-5 Benzenesulfonam...
CAS#:70-55-3 4-Toluenesulfonamide CAS#:32234-75-6 1-(4-methylphen... CAS#:664-95-9 Benzenesulfonam...

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Tosylcarbamic acid ethyl ester

Ethyl [(4-methylphenyl)sulfonyl]carbamate

ethyl N-(4-toluenesulfonyl)carbamate

ethyl tosylcarbaMate

Ethyl [(4-methylphenyl)sulphonyl]carbamate

Carbamic acid, N-[(4-methylphenyl)sulfonyl]-, ethyl ester

Tosylurethane

ethoxycarbonamide of p-toluenebenzenesulfoacid

ethyl p-tosylcarbamate

(toluene-4-sulfonyl)-carbamic acid ethyl ester

ethyl N-(tosyl)carbamate

Carbamic acid, [(4-methylphenyl)sulfonyl]-, ethyl ester

N-(4-methylphenyl)sulfonylcarbamic acid ethyl ester

2OVMSWR D1

N-(p-Tolylsulfonyl)carbamic acid ethyl ester

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ethyl [(4-methylphenyl)sulfonyl]carbamate
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ethyl [(4-methylphenyl)sulfonyl]carbamate
Price: ￥408.0/250mg ￥978.0/1g
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Ethyl tosylcarbamate
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Ethyl tosylcarbamate
Price: $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ethyl N-(4-methylphenyl)sulfonylcarbamate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

Ethyl [(4-methylphenyl)sulfonyl]carbamate suppliers

Ethyl [(4-methylphenyl)sulfonyl]carbamate price

Ethyl [(4-methylphenyl)sulfonyl]carbamate

Use of Ethyl [(4-methylphenyl)sulfonyl]carbamate

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.