4',5-Dihydroxyflavone

Modify Date: 2025-08-24 19:27:24

4',5-Dihydroxyflavone Structure
4',5-Dihydroxyflavone structure
Common Name 4',5-Dihydroxyflavone
CAS Number 6665-67-4 Molecular Weight 254.238
Density 1.4±0.1 g/cm3 Boiling Point 486.0±45.0 °C at 760 mmHg
Molecular Formula C15H10O4 Melting Point 239-240ºC
MSDS N/A Flash Point 190.0±22.2 °C

 Use of 4',5-Dihydroxyflavone


4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase.

 Names

Name 5-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
Synonym More Synonyms

 4',5-Dihydroxyflavone Biological Activity

Description 4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase.
Related Catalog
Target

Ki: 102.6 μM (LOX-1)[1]. IC50: 66 μM (α-glucosidase)[2].

References

[1]. Ribeiro D, et al. Inhibition of LOX by flavonoids: a structure-activity relationship study. Eur J Med Chem. 2014 Jan 24;72:137-45.

[2]. Proença C, et al. α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1216-1228.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 486.0±45.0 °C at 760 mmHg
Melting Point 239-240ºC
Molecular Formula C15H10O4
Molecular Weight 254.238
Flash Point 190.0±22.2 °C
Exact Mass 254.057907
PSA 70.67000
LogP 2.32
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.699
Storage condition 2-8℃

 Safety Information

HS Code 2914501900

 Synthetic Route

 Customs

HS Code 2914501900
Summary 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-
4',5-Dihydroxyflavone
5-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
4',5-dihydroxy flavone
5,4'-Dihydroxyflavone
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