K 01-162
Modify Date: 2024-01-03 19:03:38
K 01-162 structure
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Common Name | K 01-162 | ||
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| CAS Number | 677746-25-7 | Molecular Weight | 288.18200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H14BrN | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of K 01-162K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM. IC50 value: 80 nM (EC50)Target: Amyloid-βin vitro: The active drug candidate K162 (EC50 = 0.080 μM), stabilizes hydrophobic core I of Aβ42 peptide (residues 17-21) to its α-helical conformation by interacting specifically in this region. [1] K01-162 shows full MC65 protection at 125 nM, an EC50 of 80 nM, and no cytotoxicity up to 50 μM. [2]in vivo：K01-162 can reduce the brain amyloid burden that exists in both fibrillar and RIPA-soluble, non-fibrillar forms.[2] |
| Name | 7-Bromo-N,N-dimethyl-9H-fluoren-2-amine |
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| Synonym | More Synonyms |
| Description | K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM. IC50 value: 80 nM (EC50)Target: Amyloid-βin vitro: The active drug candidate K162 (EC50 = 0.080 μM), stabilizes hydrophobic core I of Aβ42 peptide (residues 17-21) to its α-helical conformation by interacting specifically in this region. [1] K01-162 shows full MC65 protection at 125 nM, an EC50 of 80 nM, and no cytotoxicity up to 50 μM. [2]in vivo：K01-162 can reduce the brain amyloid burden that exists in both fibrillar and RIPA-soluble, non-fibrillar forms.[2] |
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| Related Catalog | |
| References |
| Molecular Formula | C15H14BrN |
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| Molecular Weight | 288.18200 |
| Exact Mass | 287.03100 |
| PSA | 3.24000 |
| LogP | 4.08630 |
| Storage condition | 2-8℃ |
| K 01-162 |