N-Acetyl-3-(nitrososulfanyl)valine
N-Acetyl-3-(nitrososulfanyl)valine structure
|
Common Name | N-Acetyl-3-(nitrososulfanyl)valine | ||
|---|---|---|---|---|
| CAS Number | 67776-06-1 | Molecular Weight | 220.246 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C7H12N2O4S | Melting Point | 151ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of N-Acetyl-3-(nitrososulfanyl)valineS-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a nitric oxide donor and acts as a stable inhibitor of platelet aggregation[1][2][3][4]. |
| Name | S-Nitroso-N-acetyl-DL-penicillamine |
|---|---|
| Synonym | More Synonyms |
| Description | S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a nitric oxide donor and acts as a stable inhibitor of platelet aggregation[1][2][3][4]. |
|---|---|
| Related Catalog | |
| In Vitro | S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces toxicity of about 80% after 6 hours under normoxic conditions by releasing nitric oxide (NO)[1]. S-Nitroso-N-acetyl-DL-penicillamine has a half-time about 6 hours in in isolated rat ventricular myocytes[3]. S-Nitroso-N-acetyl-DL-penicillamine (100 µM; 30 minutes) causes sustained decrease in the basal pHi in isolated rat ventricular myocytes[3]. Cell Viability Assay[1] Cell Line: Rat liver sinusoidal endothelial cells Concentration: 2 mM, 5 mM, 10 mM Incubation Time: 2 hours, 4 hours, 6 hours, 8 hours Result: Exhibited cytotoxicity against cultivated endothelial cells. |
| In Vivo | SNAP (100μM, 300μM) causes small but significant increases of the electrically evoked [3H]-acetylcholine release in guinea-pig tracheal[4]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Melting Point | 151ºC |
| Molecular Formula | C7H12N2O4S |
| Molecular Weight | 220.246 |
| Exact Mass | 220.051773 |
| PSA | 121.13000 |
| LogP | 1.13 |
| Index of Refraction | 1.560 |
| Storage condition | −20°C |
| Water Solubility | H2O: ≥2 mg/mL |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| Precursor 10 | |
|---|---|
| DownStream 7 | |
CAS#:59-53-0![Urea,N-(2-chloroethyl)-N-nitroso-N'-[(1-oxido-3-pyridinyl)methyl]- Structure](https://image.chemsrc.com/caspic/459/70015-86-0.png)
CAS#:70015-86-0
CAS#:52-66-4
CAS#:60285-31-6
CAS#:67616-44-8
CAS#:134469-02-6
CAS#:166667-89-6
CAS#:57564-91-7
CAS#:67616-46-0
CAS#:67616-42-6
CAS#:104-91-6
CAS#:79032-48-7|
Aerobic exercise training prevents heart failure-induced skeletal muscle atrophy by anti-catabolic, but not anabolic actions.
PLoS ONE 9(10) , e110020, (2014) Heart failure (HF) is associated with cachexia and consequent exercise intolerance. Given the beneficial effects of aerobic exercise training (ET) in HF, the aim of this study was to determine if the ... |
|
|
Interferon-gamma induced cell death: Regulation and contributions of nitric oxide, cJun N-terminal kinase, reactive oxygen species and peroxynitrite.
Biochim. Biophys. Acta 1843(11) , 2645-61, (2014) Interferon-gamma (Ifnγ), a known immunomodulatory cytokine, regulates cell proliferation and survival. In this study, the mechanisms leading to the selective susceptibility of some tumor cells to Ifnγ... |
|
|
S-nitrosylation triggers ABI5 degradation to promote seed germination and seedling growth.
Nat. Commun. 6 , 8669, (2015) Plant survival depends on seed germination and progression through post-germinative developmental checkpoints. These processes are controlled by the stress phytohormone abscisic acid (ABA). ABA regula... |
| MFCD00272624 |
| N-Acetyl-3-(nitrososulfanyl)valine |
| Valine, N-acetyl-3-(nitrosothio)- |
| snap |