1-Acetyl-4-(4-hydroxyphenyl)-piperazine

Modify Date: 2025-08-20 23:03:14

1-Acetyl-4-(4-hydroxyphenyl)-piperazine Structure
1-Acetyl-4-(4-hydroxyphenyl)-piperazine structure
Common Name 1-Acetyl-4-(4-hydroxyphenyl)-piperazine
CAS Number 67914-60-7 Molecular Weight 220.268
Density 1.2±0.1 g/cm3 Boiling Point 456.5±40.0 °C at 760 mmHg
Molecular Formula C12H16N2O2 Melting Point 180-185 °C(lit.)
MSDS Chinese USA Flash Point 229.9±27.3 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 4-(1-Acetylpiperazin-4-yl)Phenol
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 456.5±40.0 °C at 760 mmHg
Melting Point 180-185 °C(lit.)
Molecular Formula C12H16N2O2
Molecular Weight 220.268
Flash Point 229.9±27.3 °C
Exact Mass 220.121185
PSA 43.78000
LogP 0.19
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.585
Storage condition -20°C Freezer
Water Solubility 4.3 g/L (20 ºC)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36-S36/37/39-S22
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933599090

 Synthetic Route

~55%

1-Acetyl-4-(4-hydroxyphenyl)-piperazine Structure

1-Acetyl-4-(4-h...

CAS#:67914-60-7

Literature: GALAPAGOS N.V. Patent: WO2008/55959 A1, 2008 ; Location in patent: Page/Page column 67 ; WO 2008/055959 A1

~92%

1-Acetyl-4-(4-hydroxyphenyl)-piperazine Structure

1-Acetyl-4-(4-h...

CAS#:67914-60-7

Literature: Stefancich; Artico; Ortar; Silvestri; Simonetti; Apuzzo Archiv der Pharmazie, 1992 , vol. 325, # 11 p. 687 - 694

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1-Acetyl-4-(4-hydroxyphenyl)-piperazine Structure

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CAS#:67914-60-7

Literature: US4435399 A1, ;

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1-Acetyl-4-(4-hydroxyphenyl)-piperazine Structure

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CAS#:67914-60-7

Literature: US4144346 A1, ;

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1-Acetyl-4-(4-hydroxyphenyl)-piperazine Structure

1-Acetyl-4-(4-h...

CAS#:67914-60-7

Literature: Archiv der Pharmazie, , vol. 325, # 11 p. 687 - 694

~%

1-Acetyl-4-(4-hydroxyphenyl)-piperazine Structure

1-Acetyl-4-(4-h...

CAS#:67914-60-7

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 4 p. 887 - 890

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1-Acetyl-4-(4-hydroxyphenyl)-piperazine Structure

1-Acetyl-4-(4-h...

CAS#:67914-60-7

Literature: Archiv der Pharmazie, , vol. 325, # 11 p. 687 - 694

~%

1-Acetyl-4-(4-hydroxyphenyl)-piperazine Structure

1-Acetyl-4-(4-h...

CAS#:67914-60-7

Literature: Journal of Heterocyclic Chemistry, , vol. 27, # 7 p. 2063 - 2068

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles5

More Articles
General approach for electrochemical detection of persistent pharmaceutical micropollutants: Application to acetaminophen.

Biosens. Bioelectron. 72 , 205-10, (2015)

We propose in this work a general and versatile methodology for electrochemical monitoring of persistent pharmaceutical micropollutants. The system presented is based on an electroactive and electropo...

New process for synthesis of 1-acetyl-4-(4-hydroxyphenyl) piperazine [J]. Zheng, CZ, et al.

Huaxue Shiji 10 , 27, (2010)

Design of new potent and selective secretory phospholipase A2 inhibitors. 6-Synthesis, structure-activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivatives. Meddad-Belhabich N, et al.

Bioorg. Med. Chem. 18(10) , 3588-3600, (2010)

 Synonyms

1-[4-(4-hydroxyphenyl)piperazin-1-yl]ethanone
ethanone, 1-4-(4-hydroxyphenyl)-1-piperazinyl-
1-[4-(4-Hydroxyphenyl)-1-piperazinyl]ethanone
EINECS 267-744-8
1-4-(4-hydroxyphenyl)piperazin-1-ylethanone
MFCD00044905
Ethanone, 1-[4-(4-hydroxyphenyl)-1-piperazinyl]-
1-Acetyl-4-(4-hydroxyphenyl)-piperazine
1-[4-(4-Hydroxyphenyl)piperazin-1-yl]ethanon
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