Terconazole

Modify Date: 2024-01-08 17:57:39

Terconazole Structure
Terconazole structure
Common Name Terconazole
CAS Number 67915-31-5 Molecular Weight 532.46200
Density 1.35g/cm3 Boiling Point 681.8ºC at 760mmHg
Molecular Formula C26H31Cl2N5O3 Melting Point 126.3ºC
MSDS Chinese USA Flash Point 366.2ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Terconazole


Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.

 Names

Name Terconazole
Synonym More Synonyms

 Terconazole Biological Activity

Description Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.
Related Catalog
In Vitro Terconazole inhibits the growth of Candida albicans ATCC 44859 in a concentration-related manner, but with modest effects noted at levels from 0.1 to 10 μM when the yeast is grown on media favoring the cell form. The inhibitory potency of terconazole on yeast cell viability varies with the strain and species of Candida tested. The susceptibility of C. albicans ATCC 44859 to terconazole is markedly enhanced when the yeast is grown on Eagle minimum essential medium, which favors mycelium formation. There is a progression of changes, from loss of mycelia formation at 0.1 μM terconazole through complete necrosis at 100 μM[1]. Terconazole blocks the morphogenetic transformation from the yeast into the filamentous form at concentrations of 0.008 to 0.05 microgram/mL[2].
In Vivo A 3-day once-daily intravaginal application of terconazole 0.8% is usually sufficient to provide a functional therapeutic period of 7 days because of prolonged high biologically active antifungal levels in the vagina. No side effects are observed at any concentration of terconazole[2].
Animal Admin Rats: The rats are infected intravaginally with C. albicans. They are treated topically twice daily for 3 days, starting 24 hours after infection with a volume of 0.2 mL of various concentrations of terconazole (0.125%, 0.25%, 0.4%, 0.5%, 1%, 2%), miconazole, clotrimazole, econazole, nystatin, or amphotericin B[2].
References

[1]. Tolman EL, et al. Anticandidal activities of terconazole, a broad-spectrum antimycotic. Antimicrob Agents Chemother. 1986 Jun;29(6):986-91.

[2]. Van Cutsem J, et al. The in vitro activity of terconazole against yeasts: its topical long-acting therapeutic efficacy in experimental vaginal candidiasis in rats. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1200-6.

 Chemical & Physical Properties

Density 1.35g/cm3
Boiling Point 681.8ºC at 760mmHg
Melting Point 126.3ºC
Molecular Formula C26H31Cl2N5O3
Molecular Weight 532.46200
Flash Point 366.2ºC
Exact Mass 531.18000
PSA 64.88000
LogP 4.46560
Index of Refraction 1.64
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335-H413
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36/37/38-53
Safety Phrases 26
RIDADR NONH for all modes of transport
RTECS TL3564600

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 Synonyms

Terconagole
MFCD05662369
Fungistat
EINECS 267-751-6
Triaconazole
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