GPNA hydrochloride
GPNA hydrochloride structure
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Common Name | GPNA hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 67953-08-6 | Molecular Weight | 303.69900 | |
| Density | N/A | Boiling Point | 590.6ºC at 760 mmHg | |
| Molecular Formula | C11H14ClN3O5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 311ºC | |
Use of GPNA hydrochlorideGPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1]. |
| Name | L-Glutamic acid γ-(p-nitroanilide) hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1]. |
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| Related Catalog | |
| Target |
ASCT2[1] |
| In Vitro | GPNA (10-1000 μM; 48 hours) induces a dose-dependent decrease of cell viability in A549 cells[1]. Cell Viability Assay[1] Cell Line: A549 cells Concentration: 10, 100, 250, 500 , and 1000 μM Incubation Time: 48 hours Result: Induced a dose-dependent decrease of cell viability, with an IC50 roughly corresponding to ~250 μM. |
| References |
| Boiling Point | 590.6ºC at 760 mmHg |
|---|---|
| Molecular Formula | C11H14ClN3O5 |
| Molecular Weight | 303.69900 |
| Flash Point | 311ºC |
| Exact Mass | 303.06200 |
| PSA | 138.24000 |
| LogP | 2.82390 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
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Donor substrate specificity of bovine kidney gamma-glutamyltransferase
Chem. Biol. Interact. 203(2) , 480-5, (2013) Highlights • Five aromatic or polycyclic aromatic glutathione conjugates were synthesized. • Enzyme kinetic studies were performed for each conjugate as a γ-glutamyltransferase (GGT) donor substrate. ... |
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Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells.
J. Steroid Biochem. Mol. Biol. 149 , 118-27, (2015) Resistance to endocrine therapies in hormone receptor (HR)-positive breast cancer is a significant clinical problem for a considerable number of patients. The oncogenic transcription factor c-MYC (her... |
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Rapid purification and characterization of γ-glutamyl-transpeptidase from shiitake mushroom (Lentinus edodes).
J. Food Sci. 77(6) , C640-5, (2012) γ-Glutamyl-transpeptidase (GGT) is one of the important enzymes in the pathway of odor formation in shiitake mushroom (Lentinus edodes). Rapid purification and characterization of GGT from shiitake mu... |
| L-GLUTAMIC ACID γ-(P-NITROANILIDE) HYDROCHLORIDE |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: GPNA hydrochloride
- Price: Negotiable
- Purity: 99.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: L-g-glutamyl-p-nitroanilide hydrochloride
- Price: $Inquiry/50mg $Inquiry/100mg $Inquiry/500mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: L-g-glutamyl-p-nitroanilide hydrochloride
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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