Name | L-Glutamic acid γ-(p-nitroanilide) hydrochloride |
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Synonyms | L-GLUTAMIC ACID γ-(P-NITROANILIDE) HYDROCHLORIDE |
Description | GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1]. |
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Related Catalog | |
Target |
ASCT2[1] |
In Vitro | GPNA (10-1000 μM; 48 hours) induces a dose-dependent decrease of cell viability in A549 cells[1]. Cell Viability Assay[1] Cell Line: A549 cells Concentration: 10, 100, 250, 500 , and 1000 μM Incubation Time: 48 hours Result: Induced a dose-dependent decrease of cell viability, with an IC50 roughly corresponding to ~250 μM. |
References |
Boiling Point | 590.6ºC at 760 mmHg |
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Molecular Formula | C11H14ClN3O5 |
Molecular Weight | 303.69900 |
Flash Point | 311ºC |
Exact Mass | 303.06200 |
PSA | 138.24000 |
LogP | 2.82390 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xi |
RIDADR | NONH for all modes of transport |