67953-08-6

67953-08-6 structure

Name: GPNA hydrochloride
Chemical Name: L-Glutamic acid γ-(p-nitroanilide) hydrochloride
CAS Number: 67953-08-6
Molecular Formula: C₁₁H₁₄ClN₃O₅
Molecular Weight: 303.69900
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-12-03 03:40:51
Modify Date: 2026-07-16 20:14:28
GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1].

Name	L-Glutamic acid γ-(p-nitroanilide) hydrochloride
Synonyms	H-GLU(PNA)-OH HCL L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE (3-cbaMoyl-1-cboxy-propyl)-(4-nitrophenyl)azaniuM chloride L-GAMMA-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE (4-amino-1-cboxy-4-keto-butyl)-(4-nitrophenyl)ammonium chloride L-glutamic acid gamma-(P-nitroanilide)hydrochlor L-GAMMA-GLUTAMYL 4-NITROANILIDE HYDROCHLORIDE L-r-Glutamyl-p-Nitroanilide Hydrochloride extrapure N-(4-nitrophenyl)-L-glutamine monohydrochloride 7-bromo-6-oxocholestan-3-yl acetate L-Glutamic acid gamma-(4-nitroanilide) monohydrochloride L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE)H YDROCHLORID GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE L-y-GLUTAMYL-p-NITROANILIDE HYDROCHLORIDE extrapure (S)-2-Amino-5-((4-nitrophenyl)amino)-5-oxopentanoic acid hydrochloride Inhibitor,GGT,SNAT,GPNA,glutamine,lung,inhibit,ASCT2,Gln,Apoptosis,GPNA hydrochloride,γ-glutamyltransferase,LAT,A549,transporter (5-azanyl-1-hydroxy-1,5-dioxo-pentan-2-yl)-(4-nitrophenyl)azanium chloride L -Glutamic acid γ-(p-nitroanilide) hydrochloride l-glutamic acid γ-(p-nitroanilide) hydrochloride gamma-L-Glutamyl-4-nitroanilideHCl L-GLUTAMIC ACID γ-(P-NITROANILIDE) HYDROCHLORIDE (5-amino-1-hydroxy-1,5-dioxopentan-2-yl)-(4-nitrophenyl)azanium chloride L-Glutamic acid g-(p-nitroanilide) hydrochloride GPNA (hydrochloride) Nintedanib esylate n-(4-nitrophenyl)-l-glutaminmonohydrochloride gamma-L-Glutamyl-p-nitroanilide HCl GPNA hydrochloride, 10 mM in DMSO

Description	GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	ASCT2[1]
In Vitro	GPNA (10-1000 μM; 48 hours) induces a dose-dependent decrease of cell viability in A549 cells[1]. Cell Viability Assay[1] Cell Line: A549 cells Concentration: 10, 100, 250, 500 , and 1000 μM Incubation Time: 48 hours Result: Induced a dose-dependent decrease of cell viability, with an IC50 roughly corresponding to ~250 μM.
References	[1]. Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport