Sorbinil
Sorbinil structure
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Common Name | Sorbinil | ||
|---|---|---|---|---|
| CAS Number | 68367-52-2 | Molecular Weight | 236.19900 | |
| Density | 1.52g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C11H9FN2O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of SorbinilSorbinil, is an Aldose reductase inhibitor (ARI).Sorbinil plays therapeutic role in treating diabetes and diabetic complications, decreases AR activity and inhibits polyol pathway, it to be found comparatively safer than other ARIs for human use[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | sorbinil |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Sorbinil, is an Aldose reductase inhibitor (ARI).Sorbinil plays therapeutic role in treating diabetes and diabetic complications, decreases AR activity and inhibits polyol pathway, it to be found comparatively safer than other ARIs for human use[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.52g/cm3 |
|---|---|
| Molecular Formula | C11H9FN2O3 |
| Molecular Weight | 236.19900 |
| Exact Mass | 236.06000 |
| PSA | 67.43000 |
| LogP | 1.30050 |
| Index of Refraction | 1.629 |
| InChIKey | LXANPKRCLVQAOG-NSHDSACASA-N |
| SMILES | O=C1NC(=O)C2(CCOc3ccc(F)cc32)N1 |
| Storage condition | 2-8°C |
This table lists relevant public references with title, journal and publication metadata for this compound.
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The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis.
PLoS ONE 7(4) , e31399, (2012) Diabetes mellitus is recognized as a leading cause of new cases of blindness. The prevalence of diabetic eye disease is expected to continue to increase worldwide as a result of the dramatic increase ... |
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Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia.
Invest. Ophthalmol. Vis. Sci. 55(5) , 2853-61, (2014) Retinal microglia become activated in diabetes and produce pro-inflammatory molecules associated with changes in retinal vasculature and increased apoptosis of retinal neurons and glial cells. We soug... |
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Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells.
Chem. Biol. Interact. 234 , 254-60, (2015) Chronic hyperglycemia is an important risk factor involved in the onset and progression of diabetic retinopathy (DR). Among other effectors, aldose reductase (AR) has been linked to the pathogenesis o... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione |
| Sorbinil |
| Sorbinilo |
| Sorbinilum |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the English name of sorbinil? |
| A: The English name of sorbinil is sorbinil. |
| Q: What is the polar surface area (PSA) of sorbinil? |
| A: Polar surface area (PSA) of sorbinil is 67.43000. |
| Q: What is the LogP of sorbinil? |
| A: LogP of sorbinil is 1.30050. |
| Q: What English synonyms does sorbinil have? |
| A: English synonyms of sorbinil: (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione, Sorbinil, Sorbinilo, Sorbinilum. |
| Q: What is the CAS number of sorbinil? |
| A: CAS number of sorbinil is 68367-52-2. |
| Q: What are the uses of sorbinil? |
| A: Main uses of sorbinil: Sorbinil, is an Aldose reductase inhibitor (ARI).Sorbinil plays therapeutic role in treating diabetes and diabetic complications, decreases AR activity and inhibits polyol pathway, it to be found comparatively safer than other ARIs for human use[1]. |
| Q: What is the molecular weight of sorbinil? |
| A: Molecular weight of sorbinil is 236.19900. |
| Q: What are the storage conditions for sorbinil? |
| A: Storage conditions for sorbinil: 2-8°C. |
| Q: What is the SMILES notation of sorbinil? |
| A: SMILES notation of sorbinil is O=C1NC(=O)C2(CCOc3ccc(F)cc32)N1. |
| Q: What is the InChIKey of sorbinil? |
| A: InChIKey of sorbinil is LXANPKRCLVQAOG-NSHDSACASA-N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |