Diethyl fluoromalonate

Modify Date: 2024-01-02 07:59:56

Diethyl fluoromalonate Structure
Diethyl fluoromalonate structure
Common Name Diethyl fluoromalonate
CAS Number 685-88-1 Molecular Weight 178.158
Density 1.1±0.1 g/cm3 Boiling Point 222.3±0.0 °C at 760 mmHg
Molecular Formula C7H11FO4 Melting Point N/A
MSDS Chinese USA Flash Point 62.2±0.0 °C
Symbol GHS05
GHS05
Signal Word Danger

 Names

Name Diethyl Fluoromalonate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 222.3±0.0 °C at 760 mmHg
Molecular Formula C7H11FO4
Molecular Weight 178.158
Flash Point 62.2±0.0 °C
Exact Mass 178.064133
PSA 52.60000
LogP 0.61
Vapour Pressure 0.1±0.4 mmHg at 25°C
Index of Refraction 1.401

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OO1670000
CHEMICAL NAME :
Malonic acid, fluoro-, diethyl ester
CAS REGISTRY NUMBER :
685-88-1
BEILSTEIN REFERENCE NO. :
1775686
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H11-F-O4
MOLECULAR WEIGHT :
178.18
WISWESSER LINE NOTATION :
2OVYFVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
70 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 6,169,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 6,169,1961

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C:Corrosive;
Risk Phrases R34
Safety Phrases S26-S36/37/39-S45-S25
RIDADR UN 3265 8/PG 2
WGK Germany 3
RTECS OO1670000
Packaging Group III
Hazard Class 8
HS Code 2917190090

 Synthetic Route

 Customs

HS Code 2917190090
Summary 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles2

More Articles
Palladium-catalyzed arylation of malonates and cyanoesters using sterically hindered trialkyl- and ferrocenyldialkylphosphine ligands.

J. Org. Chem. 67(2) , 541-55, (2002)

Palladium-catalyzed reactions of aryl bromides and chlorides with two common stabilized carbanions-enolates of dialkyl malonates and alkyl cyanoesters-are reported. An exploration of the scope of thes...

Fluorinated probes to measure carboxylesterase activities using 19F NMR spectroscopy: application to erythrocytes and Helicobacter pylori.

Arch. Biochem. Biophys. 305(2) , 252-60, (1993)

Eight fluorinated compounds were tested as putative probes to measure carboxylesterase activity employing 19F nuclear magnetic resonance spectroscopy. The method takes advantage of the sensitivity of ...

 Synonyms

MFCD00009139
EINECS 211-684-7
diethyl 2-fluoropropanedioate