Sucralose

Modify Date: 2026-07-01 17:48:57

Sucralose Structure
Sucralose structure
 Common Name Sucralose
CAS Number 56038-13-2 Molecular Weight 397.634
Density 1.7±0.1 g/cm3 Boiling Point 669.4±55.0 °C at 760 mmHg
Molecular Formula C12H19Cl3O8 Melting Point 125.5ºC
MSDS Chinese USA Flash Point 358.7±31.5 °C

 Use of Sucralose


Sucralose is an intense organochlorine artificial sweetener.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name sucralose
Synonym More Synonyms

 Sucralose Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Sucralose is an intense organochlorine artificial sweetener.
Related Catalog
In Vivo The results show that Sucralose induces significant increased incidence of all hematopoietic neoplasias in male mice exposed to 2,000 (p≤0.01), and 16,000 ppm (p≤0.01), with a significant dose-related relationship (p≤0.01). Microscopically, most of the neoplasias among male mice treated with Sucralose at 2,000 to 16,000 ppm are leukemias involving lungs, liver, spleen, lymph nodes, and bone marrow with diffuse permeation of vessels and extensive infiltration of adjacent tissues[1].
Animal Admin Sucralose is pulverized in a standard pelleted diet at concentrations 0, 500, 2,000, 8,000, and 16,000 ppm and is administered to five groups of male (n=117, 114, 90, 66, and 70, respectively) and five groups female (n=102, 105, 60, 65, and 64, respectively) Swiss mice from the 12th day of fetal life until death[1].
References

[1]. M S, et al. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Int J Occup Environ Health. 2016 Jan;22(1):7-17.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.7±0.1 g/cm3
Boiling Point 669.4±55.0 °C at 760 mmHg
Melting Point 125.5ºC
Molecular Formula C12H19Cl3O8
Molecular Weight 397.634
Flash Point 358.7±31.5 °C
Exact Mass 396.014557
PSA 128.84000
LogP 0.68
Vapour Pressure 0.0±4.6 mmHg at 25°C
Index of Refraction 1.604
InChIKey BAQAVOSOZGMPRM-QBMZZYIRSA-N
SMILES OCC1OC(OC2(CCl)OC(CCl)C(O)C2O)C(O)C(O)C1Cl
Storage condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LW5440140
CHEMICAL NAME :
alpha-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-
CAS REGISTRY NUMBER :
56038-13-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H19-Cl3-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>16 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TBSCDB Trends in Biochemical Sciences. (Elsevier Science Publishing Co., Inc., 655 Avenue of the Americas, New York, NY 10010) V.1- 1976- Volume(issue)/page/year: 3,61,1978

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-37/39
RIDADR NONH for all modes of transport
RTECS LW5440140
HS Code 2932999099

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acetate structure

4,1',6'-trichlo...

CAS#:105066-21-5

~96%

Sucralose Structure

Sucralose

CAS#:56038-13-2

Learn More
Literature: Wu, Jun Jing; Wu, Guang Li; Cai, Qing Hai; Xinyu, Shou; Li, Zi Wen; Liu, Shang; Wang, Man Tang Patent: US2008/58508 A1, 2008 ; Location in patent: Page/Page column 3 ;
3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-α-D-galactose, triacetate structure

3,4-di-O-acetyl...

CAS#:55832-20-7

~85%

Sucralose Structure

Sucralose

CAS#:56038-13-2

Learn More
Literature: EMCURE PHARMACEUTICALS LIMITED Patent: WO2007/96726 A2, 2007 ; Location in patent: Page/Page column 32 ;
Sucrose-6-acetic ester structure

Sucrose-6-aceti...

CAS#:63648-81-7

~70%

Sucralose Structure

Sucralose

CAS#:56038-13-2

Learn More
Literature: TATE and LYLE TECHNOLOGY LIMITED; WILEY, James, Edwin; JABER, Mohamad, R. Patent: WO2010/151489 A1, 2010 ; Location in patent: Page/Page column 14 ;
sucrose 4-acetate structure

sucrose 4-acetate

CAS#:63648-78-2

~48%

Sucralose Structure

Sucralose

CAS#:56038-13-2

Learn More
Literature: PHARMED MEDICARE PVT. LTD. Patent: US2009/118493 A1, 2009 ; Location in patent: Page/Page column 3 ;
6-acetyl sucrose structure

6-acetyl sucrose

CAS#:63648-85-1

~%

Sucralose Structure

Sucralose

CAS#:56038-13-2

Learn More
Literature: US2010/56773 A1, ; Page/Page column 2 ;
Sucrose-6-acetic ester structure

Sucrose-6-aceti...

CAS#:63648-81-7

~%

4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acetate structure

4,1',6'-trichlo...

CAS#:105066-21-5

Sucralose Structure

Sucralose

CAS#:56038-13-2

Learn More
Literature: US2010/160625 A1, ; Page/Page column 2 ;
1,1,1-Trimethoxyethane structure

1,1,1-Trimethox...

CAS#:1445-45-0

p-Toluenesulfonic acid structure

p-Toluenesulfon...

CAS#:104-15-4

tert-Butylamine structure

tert-Butylamine

CAS#:75-64-9

sucrose structure

sucrose

CAS#:57-50-1

~%

Detail Learn More
Literature: EP260979 B1, ;
D-Mannitol structure

D-Mannitol

CAS#:69-65-8

~%

Sucralose Structure

Sucralose

CAS#:56038-13-2

Learn More
Literature: US2011/64812 A1, ;

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles50

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

A novel ion-exclusion chromatography–mass spectrometry method to measure concentrations and cycling rates of carbohydrates and amino sugars in freshwaters

J. Chromatogr. A. 1365 , 115-23, (2014)

• Novel HPLC–MS method for carbohydrate and amino sugar analysis in freshwaters. • Rapid and efficient determination without derivatization or sample pre-concentration. • Implementation of stable isot...

Determination of eight artificial sweeteners and common Stevia rebaudiana glycosides in non-alcoholic and alcoholic beverages by reversed-phase liquid chromatography coupled with tandem mass spectrometry.

Anal. Bioanal. Chem 407(5) , 1505-12, (2015)

The method for the determination of acesulfame-K, saccharine, cyclamate, aspartame, sucralose, alitame, neohesperidin dihydrochalcone, neotame and five common steviol glycosides (rebaudioside A, rebau...

Identification, quantification, and sensory characterization of steviol glycosides from differently processed Stevia rebaudiana commercial extracts.

J. Agric. Food Chem. 62(49) , 11797-804, (2014)

Stevia rebaudiana is known for its sweet-tasting ent-kaurene diterpenoid glycosides. Several manufacturing strategies are currently employed to obtain Stevia sweeteners with the lowest possible off-fl...

 SucraloseBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

(2R,3R,4R,5R,6R)-2-{[(2R,3S,4S,5S)-2,5-Bis(chloromethyl)-3,4-dihydroxytetrahydro-2-furanyl]oxy}-5-chloro-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol
1',4,6'-Trichlorogalactosucrose
1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl 4-chloro-4-deoxy-α-D-galactopyranoside
trichlorosucrose
(2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol
MFCD03648615
1,6-dichloro-1,6-dideoxy-b-D-fructofuranosyl 4-chloro-4-deoxy-a-D-galactopyranoside
Sucralose
EINECS 259-952-2
1,6-Dichlor-1,6-dideoxy-β-D-fructofuranosyl-4-chlor-4-deoxy-α-D-galactopyranoside
4,1',6'-Trichloro-4,1',6'-trideoxygalacto-sucrose
1,6-Dichloro-1,6-dideoxy-b-D-fructofuranosyl-4-chloro-4-deoxy-a-D-galactopyranoside
splenda
UNII-96K6UQ3ZD4

 Sucralose | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular weight of sucralose?
A: Molecular weight of sucralose is 397.634.
Q: What are the storage conditions for sucralose?
A: Storage conditions for sucralose: Hygroscopic, -20°C Freezer, Under Inert Atmosphere.
Q: What are the uses of sucralose?
A: Main uses of sucralose: Sucralose is an intense organochlorine artificial sweetener.
Q: What is the safety information for sucralose?
A: Safety information for sucralose: 26-37/39.
Q: What is the polar surface area (PSA) of sucralose?
A: Polar surface area (PSA) of sucralose is 128.84000.
Q: What is the CAS number of sucralose?
A: CAS number of sucralose is 56038-13-2.
Q: What is the melting point of sucralose?
A: Melting point of sucralose is 125.5ºC.
Q: What is the molecular formula of sucralose?
A: Molecular formula of sucralose is C12H19Cl3O8.
Q: What is the boiling point of sucralose?
A: Boiling point of sucralose is 669.4±55.0 °C at 760 mmHg.
Q: What are the upstream materials of sucralose?
A: Related upstream materials(CAS) of sucralose: 105066-21-5;55832-20-7;63648-81-7;63648-78-2;1445-45-0;104-15-4;75-64-9;57-50-1;69-65-8.

 Sucralosefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
BioBioPha
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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Chemsrc provides Sucralose(CAS#:56038-13-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Sucralose are included as well.>> amp version: Sucralose

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