fusidic acid

Modify Date: 2024-01-01 23:00:00

fusidic acid structure	Common Name	fusidic acid
	CAS Number	6990-06-3	Molecular Weight	516.709
	Density	1.2±0.1 g/cm3	Boiling Point	635.6±55.0 °C at 760 mmHg
	Molecular Formula	C₃₁H₄₈O₆	Melting Point	190-192ºC
	MSDS	Chinese USA	Flash Point	197.7±25.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of fusidic acid

Fusidic acid (Fusidate) is a bacteriostatic antibiotic[1][2][3].

Name	fusidic acid
Synonym	More Synonyms

Description	Fusidic acid (Fusidate) is a bacteriostatic antibiotic[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Bacterial[1][2][3]
References	[1]. Falagas ME, et al. Potential of old-generation antibiotics to address current need for new antibiotics. Expert Rev Anti Infect Ther. 2008 Oct;6(5):593-600. [2]. Leclercq R, et al. In vitro activity of fusidic acid against streptococci isolated from skin and soft tissue infections. J Antimicrob Chemother. 2000 Jan;45(1):27-9. [3]. Spelman D, et al. Fusidic acid in skin and soft tissue infections. Int J Antimicrob Agents. 1999 Aug;12 Suppl 2:S59-66.

Density	1.2±0.1 g/cm3
Boiling Point	635.6±55.0 °C at 760 mmHg
Melting Point	190-192ºC
Molecular Formula	C₃₁H₄₈O₆
Molecular Weight	516.709
Flash Point	197.7±25.0 °C
Exact Mass	516.345093
PSA	104.06000
LogP	6.41
Vapour Pressure	0.0±4.2 mmHg at 25°C
Index of Refraction	1.558
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC1350000

CHEMICAL NAME :: 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3-alpha,4-alpha, 8-alpha,9-beta,11-alpha,13-alpha,14-beta,16-beta,17Z) -

CAS REGISTRY NUMBER :: 6990-06-3

LAST UPDATED :: 199603

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C31-H48-O6

MOLECULAR WEIGHT :: 516.79

WISWESSER LINE NOTATION :: L E5 B666 FYTJ A CQ FUYVQ3UY GOV1 I J N OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 420 mg/kg/2W-I

TOXIC EFFECTS :: Blood - leukopenia Blood - thrombocytopenia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 15 gm/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Insect - Drosophila melanogaster Cells - not otherwise specified

DOSE/DURATION :: 100 mg/L

REFERENCE :: CLDFAT Cell Differentiation. (Limerick, Ireland) V.1-24, 1972-88. Volume(issue)/page/year: 2,97,1973

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	36
RIDADR	NONH for all modes of transport
RTECS	RC1350000
HS Code	2942000000

HS Code	2942000000

Antibiotic exposure in a low-income country: screening urine samples for presence of antibiotics and antibiotic resistance in coagulase negative staphylococcal contaminants.

PLoS ONE 9(12) , e113055, (2014)

Development of antimicrobial resistance has been assigned to excess and misuse of antimicrobial agents. Staphylococci are part of the normal flora but are also potential pathogens that have become ess...

Multiple roles for Enterococcus faecalis glycosyltransferases in biofilm-associated antibiotic resistance, cell envelope integrity, and conjugative transfer.

Antimicrob. Agents Chemother. 59 , 4094-105, (2015)

The emergence of multidrug-resistant bacteria and the limited availability of new antibiotics are of increasing clinical concern. A compounding factor is the ability of microorganisms to form biofilms...

Enterococcus faecalis 6-phosphogluconolactonase is required for both commensal and pathogenic interactions with Manduca sexta.

Infect. Immun. 83(1) , 396-404, (2014)

Enterococcus faecalis is a commensal and pathogen of humans and insects. In Manduca sexta, E. faecalis is an infrequent member of the commensal gut community, but its translocation to the hemocoel res...

(2Z)-2-[(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoic acid

Fucidic acid

Fusidate sodium

EINECS 230-256-0

fusidic acid

Fusidin

FUCIDIN

(2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid

(2Z)-2-[(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoic acid

Fusidate

5-Heptenoic acid, 2-[(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methyl-, (2Z)-

Ramycin

fusdic acid

(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-Acetoxy-3,11-dihydroxy-4,8,14-trimethyl-18-norcholesta-17,24-dien-21-oic acid

Fucithalmic

Fucidin acid

MFCD00865135

3,11,16-Trihydroxy-4,8,10,14-tetramethyl-17-(1'-carboxyisohept-4'-enylidene)cyclopentanoperhydrophenanthrene 16-Acetate

FusidicAcid

29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-

(3a,4a,8a,9b,11a,13a,14b,16b,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic Acid

Diethanolamine fusidate

Fusidine

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: fusidic acid
Price: ￥708.0/1g
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Anhydrous Fusidic Acid
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Fusidine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: fusidic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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