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70-07-5

70-07-5 structure
70-07-5 structure
  • Name: mephenoxalone
  • Chemical Name: 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one
  • CAS Number: 70-07-5
  • Molecular Formula: C11H13NO4
  • Molecular Weight: 223.23
  • Catalog: Signaling Pathways Apoptosis Bcl-2 Family
  • Create Date: 2018-08-25 11:59:21
  • Modify Date: 2025-08-25 21:41:34
  • Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc[1].
Name 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one
Synonyms Control-OM
5-[(2-Methoxyphenoxy)methyl]-1,3-oxazolidin-2-one
2-Oxazolidinone, 5-[(2-methoxyphenoxy)methyl]-
Mefenoxalona
Mefenoxalone
EINECS 200-723-3
mephenoxalone
5-({[2-(methyloxy)phenyl]oxy}methyl)-1,3-oxazolidin-2-one
Moderamin
Methoxydone
5-[(2-Methoxyphenoxy)methyl]-2-oxazolidinone
Methoxydon
Dorsiflex
Description Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc[1].
Related Catalog
References

[1]. K F BENITZ, et al. Toxicity studies on mephenoxalone in rats and dogs. Toxicol Appl Pharmacol (IF: 4.22; Q2). 1962 Mar;4:220-37.  

Density 1.2±0.1 g/cm3
Boiling Point 440.0±18.0 °C at 760 mmHg
Molecular Formula C11H13NO4
Molecular Weight 223.23
Flash Point 219.9±21.2 °C
Exact Mass 223.084457
PSA 56.79000
LogP 1.32
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.521

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RQ3500000
CHEMICAL NAME :
2-Oxazolidinone, 5-((o-methoxyphenoxy)methyl)-
CAS REGISTRY NUMBER :
70-07-5
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C11-H13-N-O4
MOLECULAR WEIGHT :
223.25
WISWESSER LINE NOTATION :
T5MVOTJ D1OR BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3820 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,642,1964
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,198,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 11,212,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RAMAAB Revista de la Asociacion Medica Argentina. (Buenos Aires, Argentina) V.1-89, 1915-76. Discontinued. Volume(issue)/page/year: 74,82,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30330 mg/kg/30D-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in ovarian weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
18 gm/kg/30D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Liver - other changes Blood - normocytic anemia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
87 gm/kg/26W-I
TOXIC EFFECTS :
Behavioral - ataxia Blood - normocytic anemia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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