Glutathione

Modify Date: 2024-01-02 17:58:18

Glutathione structure	Common Name	Glutathione
	CAS Number	70-18-8	Molecular Weight	307.323
	Density	1.4±0.1 g/cm3	Boiling Point	754.5±60.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₇N₃O₆S	Melting Point	182-192ºC
	MSDS	Chinese USA	Flash Point	410.1±32.9 °C

Use of Glutathione

L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

Name	Glutathione
Synonym	More Synonyms

Description	L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Biochemical Assay Reagents Research Areas >> Cancer Research Areas >> Neurological Disease Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	L-Glutathione reduced is a non-protein thiol widely exists in living cells. L-Glutathione reduced plays important biological functions in the organism, including protein and DNA synthesis, enzyme activity, metabolism and cell protection. L-Glutathione reduced is capable of scavenging oxygen-derived free radicals and is established to be a marker of oxidative stress[1].
References	[1]. Pereira-Rodrigues N, et al. Electrocatalytic activity of cobalt phthalocyanine CoPc adsorbed on a graphite electrode for the oxidation of reduced L-glutathione (GSH) and the reduction of its disulfide (GSSG) at physiological pH. Bioelectrochemistry. 2007 Jan;70(1):147-54.

Density	1.4±0.1 g/cm3
Boiling Point	754.5±60.0 °C at 760 mmHg
Melting Point	182-192ºC
Molecular Formula	C₁₀H₁₇N₃O₆S
Molecular Weight	307.323
Flash Point	410.1±32.9 °C
Exact Mass	307.083801
PSA	197.62000
LogP	-0.87
Vapour Pressure	0.0±5.5 mmHg at 25°C
Index of Refraction	1.572

Glutathione MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MC0556000

CHEMICAL NAME :: Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-

CAS REGISTRY NUMBER :: 70-18-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C10-H17-N3-O6-S

MOLECULAR WEIGHT :: 307.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4020 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2238 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1250 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 10 mmol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 31,265,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83371 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83371 No. of Facilities: 238 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 3078 (estimated) No. of Female Employees: 2121 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R68
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	MC0556000
HS Code	2930909090

Precursor 9
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HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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L-Glutathione Reduced

Tathion

L-Norvaline, 5-[[(1R,2Z)-2-[(carboxymethyl)imino]-2-hydroxy-1-(mercaptomethyl)ethyl]imino]-5-hydroxy-, (5Z)-

(5Z)-5-({(1Z,2R)-1-[(Carboxymethyl)imino]-1-hydroxy-3-sulfanyl-2-propanyl}imino)-5-hydroxy-L-norvaline

Deltathione

Glycine, N- (N-L-γ-glutamyl-L-cysteinyl)-

L-γ-Glutamyl-L-cysteinylglycine

Copren

Glycine, L-γ-glutamyl-L-cysteinyl-

Isethion

Glutathione reduced

GSH

Glutathione

Reduced glutathione

(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid

L-γ-Glutamyl-L-cysteiylglycin

Glutathiol

MFCD00065939

EINECS 200-725-4

(2S)-2-Amino-5-({(2R)-1-[(carboxymethyl)amino]-1-oxo-3-sulfanyl-2-propanyl}amino)-5-oxopentanoic acid

Glutathione-SH

N-(N-L-g-Glutamyl-L-cysteinyl)glycine

Glutinal

L-Glutathione

γ-glutamyl-cysteinyl-glycine

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Glutathione

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