5-HETE

Modify Date: 2024-01-04 11:21:26

5-HETE Structure
5-HETE structure
Common Name 5-HETE
CAS Number 70608-72-9 Molecular Weight 320.466
Density 1.0±0.1 g/cm3 Boiling Point 487.7±45.0 °C at 760 mmHg
Molecular Formula C20H32O3 Melting Point N/A
MSDS N/A Flash Point 262.8±25.2 °C

 Use of 5-HETE


5(S)-HETE is an endogenous metabolite present in Blood that can be used for the research of Rheumatoid Arthritis, Rhinitis and Asthma[1][2].

 Names

Name 5(s)-hete
Synonym More Synonyms

 5-HETE Biological Activity

Description 5(S)-HETE is an endogenous metabolite present in Blood that can be used for the research of Rheumatoid Arthritis, Rhinitis and Asthma[1][2].
Related Catalog
In Vitro Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].
References

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.  

[2]. Chavis C, et al. A method for the measurement of plasma hydroxyeicosatetraenoic acid levels. Anal Biochem. 1999 Jun 15;271(1):105-8.  

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 487.7±45.0 °C at 760 mmHg
Molecular Formula C20H32O3
Molecular Weight 320.466
Flash Point 262.8±25.2 °C
Exact Mass 320.235138
PSA 57.53000
LogP 5.56
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.514

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JX3873000
CHEMICAL NAME :
6,8,11,14-Eicosatetraenoic acid, 5-hydroxy-, (S-(E,Z,Z,Z))-
CAS REGISTRY NUMBER :
70608-72-9
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H32-O3
MOLECULAR WEIGHT :
320.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
5 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 10,1029,1989

 Safety Information

Hazard Codes F,Xi
Risk Phrases 11-36/37/38
RIDADR UN 1170 3/PG 2

 Synonyms

5-hydroxy-6,8,11,14-eicosatetraenoicacid
5(S)-HETE
[S-(E,Z,Z,Z)]-5-Hydroxy-6,8,11,14-eicosatetraenoic Acid
5-Hpete
5-HETE
5-Hydroxyicosatetraenoic acid
(5S,6E,8Z,11Z,14Z)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid
(5S,6E,8Z,11Z,14Z)-5-Hydroxy-6,8,11,14-icosatetraenoic acid
5-hydroxyeicosatetraenoicacid
6,8,11,14-Eicosatetraenoic acid, 5-hydroxy-, (5S,6E,8Z,11Z,14Z)-
(S)-5-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic Acid
(5S,6E,8Z,11Z,14Z)-5-Hydroxy-6,8,11,14-eicosatetraenoic acid
5-Hydroxyeicosatetraenoate
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