Nargenicin A1

Modify Date: 2025-08-27 09:31:52

Nargenicin A1 Structure
Nargenicin A1 structure
Common Name Nargenicin A1
CAS Number 70695-02-2 Molecular Weight 515.60
Density 1.31g/cm3 Boiling Point 718.3ºC at 760 mmHg
Molecular Formula C28H37NO8 Melting Point N/A
MSDS N/A Flash Point 388.2ºC

 Use of Nargenicin A1


Nargenicin A1 is an antibiotic agent against various Gram-positive bacteria. Nargenicin A1 shows anti-inflammatory activity. Nargenicin A1 protects HINAE cells against Tacrolimus (HY-13756)-induced DNA damage and apoptosis. Nargenicin A1 can also be used for the research of acute myeloid leukemia[1].

 Names

Name nargenicin a,

 Nargenicin A1 Biological Activity

Description Nargenicin A1 is an antibiotic agent against various Gram-positive bacteria. Nargenicin A1 shows anti-inflammatory activity. Nargenicin A1 protects HINAE cells against Tacrolimus (HY-13756)-induced DNA damage and apoptosis. Nargenicin A1 can also be used for the research of acute myeloid leukemia[1].
Related Catalog
References

[1]. Da Hye Kwon, et al. Nargenicin A1 attenuates lipopolysaccharide-induced inflammatory and oxidative response by blocking the NF-κB signaling pathway. EXCLI J. 2021 May 28;20:968-982.  

[2]. Dhakal D, et al. Characterization of Tailoring Steps of Nargenicin A1 Biosynthesis Reveals a Novel Analogue with Anticancer Activities. ACS Chem Biol. 2020 Jun 19;15(6):1370-1380.  

 Chemical & Physical Properties

Density 1.31g/cm3
Boiling Point 718.3ºC at 760 mmHg
Molecular Formula C28H37NO8
Molecular Weight 515.60
Flash Point 388.2ºC
Exact Mass 515.25200
PSA 127.31000
LogP 2.40040
Index of Refraction 1.595
InChIKey YEUSSARNQQYBKH-QTCPSXGDSA-N
SMILES COC1CC2C=CC3C4OC2(C(C)=CC(C)C(C(C)O)OC1=O)C3C(O)C(C)C4OC(=O)c1ccc[nH]1
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