(R)-Mephenytoin

Modify Date: 2024-01-05 11:29:03

(R)-Mephenytoin Structure
(R)-Mephenytoin structure
Common Name (R)-Mephenytoin
CAS Number 71140-51-7 Molecular Weight 218.25200
Density 1.154g/cm3 Boiling Point N/A
Molecular Formula C12H14N2O2 Melting Point 137-138ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of (R)-Mephenytoin


(R)-Mephenytoin ((-)-Mephenytoin), the R-enantiomer of Mephenytoin. Mephenytoin is an Anticonvulsant agent[1][2].

 Names

Name (R)-Mephenytoin
Synonym More Synonyms

 (R)-Mephenytoin Biological Activity

Description (R)-Mephenytoin ((-)-Mephenytoin), the R-enantiomer of Mephenytoin. Mephenytoin is an Anticonvulsant agent[1][2].
Related Catalog
In Vitro (R)-Mephenytoin can be N-demethylated by the cytochrome P450 (CYP) isoform CYP2C9 to form the metabolite 5-phenyl-5-ethylhydantoin (nirvanol)[1].
References

[1]. Meier UT, et, al. Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography. Anal Biochem. 1985 Dec;151(2):286-91.

[2]. Relling MV, et, al. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. J Pharmacol Exp Ther. 1990 Jan;252(1):442-7.

 Chemical & Physical Properties

Density 1.154g/cm3
Melting Point 137-138ºC
Molecular Formula C12H14N2O2
Molecular Weight 218.25200
Exact Mass 218.10600
PSA 49.41000
LogP 1.74020
Index of Refraction 1.541

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases 22-36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport

 Synonyms

(r)-(-)-mephenytoin