3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-quinolin-2-ol

• 常用名: 3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-quinolin-2-ol
• 英文名: NCGC00029283
• CAS号: 714240-31-0
• 分子量: 337.305
• 密度: 1.4±0.1 g/cm3
• 沸点: 576.7±60.0 °C at 760 mmHg
• 分子式: C₁₈H₁₂FN₃O₃
• 熔点: N/A
• 闪点: 302.6±32.9 °C

用途

NCGC00029283是一种werner综合征解旋酶核酸酶(WRN)解旋酶抑制剂,WRN、BLM和FANJ解旋酶的IC50分别为2.3μM、12.5μM和3.4μM[1]。

名称

• 中文名: 3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-quinolin-2-ol
• 英文名: 3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-quinolin-2-ol

生物活性

• 描述: NCGC00029283是一种werner综合征解旋酶核酸酶(WRN)解旋酶抑制剂,WRN、BLM和FANJ解旋酶的IC50分别为2.3μM、12.5μM和3.4μM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
• 体外研究: NCGC00029283(0-100μM；24-72小时)有效阻止U2-OS细胞的细胞增殖[1]。细胞增殖试验[1]细胞系：U2-OS细胞浓度：1μM、10μM、100μM培养时间：24小时、48小时、72小时结果：U2-OS细胞增殖减少。
• 参考文献:

  [1]. Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN). PLoS One. 2019 Jan 9;14(1):e0210525.

物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 576.7±60.0 °C at 760 mmHg
• 分子式: C₁₈H₁₂FN₃O₃
• 分子量: 337.305
• 闪点: 302.6±32.9 °C
• 精确质量: 337.086273
• LogP: 5.61
• InChIKey: FJQADEHMIMENRE-UHFFFAOYSA-N
• SMILES: COc1ccc2[nH]c(=O)c(-c3noc(-c4ccc(F)cc4)n3)cc2c1
• 外观性状: 固体
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.647
• 储存条件: 2-8°C，密封，干燥

安全信息

• 危害码 (欧洲): Xi

靶点实验

查看更多实验

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实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

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英文别名

• 3-[5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy-2(1H)-quinolinone
• 3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-6-methoxy-quinolin-2-ol