Avermectin

Modify Date: 2024-01-02 16:43:03

Avermectin Structure
Avermectin structure
 Common Name Avermectin
CAS Number 71751-41-2 Molecular Weight 1732.13
Density 1.2±0.1 g/cm3 Boiling Point 940.9±65.0 °C at 760 mmHg
Molecular Formula C95H142O28 Melting Point 150-155°C
MSDS Chinese USA Flash Point 268.1±27.8 °C
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09		 Signal Word Danger

 Use of Avermectin


Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic. IC50 Value: N/ATarget: AntiparasiticAvermectin B1 is a mixture of avermectins containing more than 80% avermectin B1a and less than 20% avermectin B1b. These two components, B1a and B1b have very similar biological and toxicological properties. The avermectins are insecticidal and antihelmintic compounds derived from various laboratory broths fermented by the soil bacterium Streptomyces avermitilis. Avermectin B1 is a natural fermentation product of this bacterium.

 Names

Name Abamectin
Synonym More Synonyms

 Avermectin Biological Activity

Description Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic. IC50 Value: N/ATarget: AntiparasiticAvermectin B1 is a mixture of avermectins containing more than 80% avermectin B1a and less than 20% avermectin B1b. These two components, B1a and B1b have very similar biological and toxicological properties. The avermectins are insecticidal and antihelmintic compounds derived from various laboratory broths fermented by the soil bacterium Streptomyces avermitilis. Avermectin B1 is a natural fermentation product of this bacterium.
Related Catalog
References

[1]. Mogg TD, Pollitt CC, Willmore JP, Thompson H.Efficacy of avermectin B1 given orally against equine intestinal strongyles and Onchocera microfilaria.Aust Vet J. 1990 Nov;67(11):399-401.

[2]. De Chaneet GC, Casey R, Dixon FF, Besier RB, Mitchell RK.Effect of avermectin B1 and benzimidazole anthelmintics on worm egg output of treated cattle.Aust Vet J. 1988 Mar;65(3):85-6.

[3]. Seaman JT, Eagleson JS, Carrigan MJ, Webb RF.Avermectin B1 toxicity in a herd of Murray Grey cattle.Aust Vet J. 1987 Sep;64(9):284-5.

[4]. Murty US, Jyothi KN, Jamil K.Effect of avermectin B1 (L-676) a metabolite from Streptomyces avermilitis on immatures of Culex quinquefasciatus.Indian J Med Res. 1987 May;85:539-41.

[5]. Parrish MD, Roberts RB.Toxicity of avermectin B1 to larval yellowjackets, Vespula maculifrons (Hymenoptera: Vespidae).J Econ Entomol. 1984 Jun;77(3):769-72.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 940.9±65.0 °C at 760 mmHg
Melting Point 150-155°C
Molecular Formula C95H142O28
Molecular Weight 1732.13
Flash Point 268.1±27.8 °C
PSA 170.06000
LogP 6.51
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.571

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CL1203000
CHEMICAL NAME :
Avermectin B(sub 1)
CAS REGISTRY NUMBER :
71751-41-2
LAST UPDATED :
199409

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,3,1989
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1100 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1740 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 60,289,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
84600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Bird - domestic
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988

 Safety Information

Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H300 + H330-H361d-H372-H410
Precautionary Statements P201-P260-P273-P301 + P310 + P330-P304 + P340 + P310-P403 + P233
Target Organs Nervous system
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+,N
Risk Phrases R20
Safety Phrases 36/37/39-45-60-61
RIDADR 2588
RTECS CL1203000
Packaging Group II
Hazard Class 6.1(a)
HS Code 2932999099

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles29

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 Synonyms

MFCD01769550
EINECS 200-096-6
avomec
mk936
zephyr
affirm
SADDLE
Zephy
AVM
avidec
Avermectin B1
ACIMIC
avid
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Related Compounds: More...
Avermectin
73989-17-0
avermectin B1
65195-52-0
avermectin B2
65195-57-5
Avermectin B1b
65195-56-4
Avermectin B2a
135680-93-2
Avermectin B1a
65195-55-3
avermectin A1a
65195-51-9
avermectin A2b
65195-54-2
avermectin A2a
65195-53-1
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Chemsrc provides Avermectin(CAS#:71751-41-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Avermectin are included as well.>> amp version: Avermectin

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