N-Biotinyl-6-aminohexanoic acid

Modify Date: 2025-08-20 15:14:29

N-Biotinyl-6-aminohexanoic acid Structure
N-Biotinyl-6-aminohexanoic acid structure
Common Name N-Biotinyl-6-aminohexanoic acid
CAS Number 72040-64-3 Molecular Weight 357.46800
Density 1.2g/cm3 Boiling Point 721.3ºC at 760 mmHg
Molecular Formula C16H27N3O4S Melting Point 220-230ºC (dec.)
MSDS USA Flash Point 390ºC

 Use of N-Biotinyl-6-aminohexanoic acid


N-Biotinyl-6-aminohexanoic acid (N-(+)-Biotinyl-6-aminohexanoic acid) can be used to perform biotinylation[1].

 Names

Name N-Biotinylcaproic Acid
Synonym More Synonyms

 N-Biotinyl-6-aminohexanoic acid Biological Activity

Description N-Biotinyl-6-aminohexanoic acid (N-(+)-Biotinyl-6-aminohexanoic acid) can be used to perform biotinylation[1].
Related Catalog
In Vitro Synthesis of p-nitrophenyl N-acetyllactosaminide with β-D-galactosidase, chemical reduction of the p-nitrophenyl group, and sialylation with sialyltransferase. The p-aminophenyl glycosides are then successfully biotin-labeled through the coupling with N-(+)-biotinyl-6- aminohexanoic acid to afford biotinylated oligosaccharides with an aminohexanosyl group and phenyl group as the spacers between the biotin and glycan[1]. The SERS (surface-enhanced Raman scattering) of cyclohexyl isocyanide that silver nanoparticles modified with N-(+)-biotinyl-6-aminocaproic acid and cyclohexyl isocyanide can be anchored on a separate biotinylated substrate via the avidin-biotin interaction[2].
References

[1]. Zeng X, et al. Effective chemoenzymatic synthesis of p-aminophenyl glycosides of sialyl N-acetyllactosaminide and analysis of their interactions with lectins. Carbohydr Res. 2007 Jul 2;342(9):1244-8.

[2]. Kim K, et al. microAg particle-based molecular sensing/recognition via surface-enhanced Raman spectroscopy. Biosens Bioelectron. 2007 Jan 15;22(6):1000-5.

 Chemical & Physical Properties

Density 1.2g/cm3
Boiling Point 721.3ºC at 760 mmHg
Melting Point 220-230ºC (dec.)
Molecular Formula C16H27N3O4S
Molecular Weight 357.46800
Flash Point 390ºC
Exact Mass 357.17200
PSA 132.83000
LogP 2.52190
Index of Refraction 1.532

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F: Flammable;
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport

 Synthetic Route

~76%

N-Biotinyl-6-aminohexanoic acid Structure

N-Biotinyl-6-am...

CAS#:72040-64-3

Literature: Skander, Myriem; Humbert, Nicolas; Collot, Jerome; Gradinaru, Julieta; Klein, Gerard; Loosli, Andreas; Sauser, Jerome; Zocchi, Andrea; Gilardoni, Francois; Ward, Thomas R. Journal of the American Chemical Society, 2004 , vol. 126, # 44 p. 14411 - 14418

~79%

N-Biotinyl-6-aminohexanoic acid Structure

N-Biotinyl-6-am...

CAS#:72040-64-3

Literature: Shi, Haibin; Liu, Kai; Xu, Ashley; Yao, Shao Q. Chemical Communications, 2009 , # 33 p. 5030 - 5032

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N-Biotinyl-6-aminohexanoic acid Structure

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CAS#:72040-64-3

Literature: US2012/232262 A1, ; Page/Page column 3 ;

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N-Biotinyl-6-aminohexanoic acid Structure

N-Biotinyl-6-am...

CAS#:72040-64-3

Literature: US2012/232262 A1, ;

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N-Biotinyl-6-aminohexanoic acid Structure

N-Biotinyl-6-am...

CAS#:72040-64-3

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 4 p. 309 - 322

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N-Biotinyl-6-aminohexanoic acid Structure

N-Biotinyl-6-am...

CAS#:72040-64-3

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 4 p. 309 - 322

 Articles5

More Articles
In vivo labeling of Escherichia coli cell envelope proteins with N-hydroxysuccinimide esters of biotin. Bradburne JA, Godfrey P, et al.

Appl. Environ. Microbiol. 59 , 663-668, (2993)

(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor.

Mol. Pharmacol. 68 , 1623-35, (2005)

The CB1 cannabinoid receptor has been shown to play important physiological roles in the central nervous system, as well as peripherally, and is a target for development of therapeutic medications. To...

microAg particle-based molecular sensing/recognition via surface-enhanced Raman spectroscopy.

Biosens. Bioelectron. 22 , 1000-1005, (2007)

In this study, we demonstrate that powders of commercially available 2-microm-sized Ag (microAg) can be used as a core material for constructing molecular sensing/recognition units operating via surfa...

 Synonyms

6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoic acid
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