Chk2 Inhibitor

Modify Date: 2024-01-03 20:46:09

Chk2 Inhibitor Structure
Chk2 Inhibitor structure
Common Name Chk2 Inhibitor
CAS Number 724708-21-8 Molecular Weight 295.29600
Density N/A Boiling Point N/A
Molecular Formula C15H13N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Chk2 Inhibitor


Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect[1].

 Names

Name indoloazepine

 Chk2 Inhibitor Biological Activity

Description Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect[1].
Related Catalog
Target

Chk2:13.5 nM (IC50)

Chk1:220.4 nM (IC50)

References

[1]. Nguyen TNT, et, al. Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors. ACS Chem Biol. 2012 Jan 20;7(1):172-84.

 Chemical & Physical Properties

Molecular Formula C15H13N5O2
Molecular Weight 295.29600
Exact Mass 295.10700
PSA 112.37000
LogP 1.25050