Psora-4
Psora-4 structure
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Common Name | Psora-4 | ||
|---|---|---|---|---|
| CAS Number | 724709-68-6 | Molecular Weight | 334.36500 | |
| Density | 1.246g/cm3 | Boiling Point | 537.7ºC at 760 mmHg | |
| Molecular Formula | C21H18O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 279ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Psora-4Psora-4 is a potent and selective inhibitor of Kv1.3 (voltage-gated potassium channels) with an EC50 of 3 nM[1]. Psora-4 has immunosuppressive activity and inhibits proliferation of human and rat myelin-specific effector memory T cells in vitro[2]. |
| Name | 4-(4-phenylbutoxy)furo[3,2-g]chromen-7-one |
|---|---|
| Synonym | More Synonyms |
| Description | Psora-4 is a potent and selective inhibitor of Kv1.3 (voltage-gated potassium channels) with an EC50 of 3 nM[1]. Psora-4 has immunosuppressive activity and inhibits proliferation of human and rat myelin-specific effector memory T cells in vitro[2]. |
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| Related Catalog | |
| References |
| Density | 1.246g/cm3 |
|---|---|
| Boiling Point | 537.7ºC at 760 mmHg |
| Molecular Formula | C21H18O4 |
| Molecular Weight | 334.36500 |
| Flash Point | 279ºC |
| Exact Mass | 334.12100 |
| PSA | 52.58000 |
| LogP | 4.94090 |
| Index of Refraction | 1.626 |
| InChIKey | JJAWGNIQEOFURP-UHFFFAOYSA-N |
| SMILES | O=c1ccc2c(OCCCCc3ccccc3)c3ccoc3cc2o1 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335-H413 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | C |
| RIDADR | NONH for all modes of transport |
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Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells.
CNS Neurosci. Ther. 21 , 558-67, (2015) The self-repair ability of neural progenitor cells (NPCs) has been found to be activated and protected in several therapies helpful in multiple sclerosis (MS), an inflammatory demyelinating disease of... |
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K+ channels as targets for specific immunomodulation.
Trends Pharmacol. Sci. 25 , 280-289, (2004) The voltage-gated Kv1.3 channel and the Ca(2+)-activated IKCa1 K(+) channel are expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation and differentiation. The c... |
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Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.
Mol. Pharmacol. 65 , 1364-1374, (2004) The lymphocyte potassium channel Kv1.3 is widely regarded as a promising new target for immunosuppression. To identify a potent small-molecule Kv1.3 blocker, we synthesized a series of 5-phenylalkoxyp... |
| Lopac-P-9872 |
| 5-(4-Phenylbutoxy)psoralen |
| Psora-4 |