2,4,6-Tri-tert-butylphenol

Modify Date: 2026-06-30 21:08:50

2,4,6-Tri-tert-butylphenol structure	Common Name	2,4,6-Tri-tert-butylphenol
	CAS Number	732-26-3	Molecular Weight	262.430
	Density	0.9±0.1 g/cm3	Boiling Point	278.0±0.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₃₀O	Melting Point	125-130 °C(lit.)
	MSDS	Chinese USA	Flash Point	129.3±8.4 °C
	Symbol	GHS07, GHS09	Signal Word	Warning

Summary: 2,4,6-Tri-tert-butylphenol (CAS number: 732-26-3) is a yellow crystalline powder with molecular formula C18H30O and molecular weight 262.430. This compound is used as a rubber anti-aging agent, plastic and rubber anti-aging agent, and in organic synthesis. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	2,4,6-Tri-tert-butylphenol
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	0.9±0.1 g/cm3
Boiling Point	278.0±0.0 °C at 760 mmHg
Melting Point	125-130 °C(lit.)
Molecular Formula	C₁₈H₃₀O
Molecular Weight	262.430
Flash Point	129.3±8.4 °C
Exact Mass	262.229675
PSA	20.23000
LogP	6.55
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.490
InChIKey	PFEFOYRSMXVNEL-UHFFFAOYSA-N
SMILES	CC(C)(C)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1
Storage condition	-20°C
Water Solubility	insoluble

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

2,4,6-Tri-tert-butylphenol MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN3570000

CHEMICAL NAME :: Phenol, 2,4,6-tris(1,1-dimethylethyl)-

CAS REGISTRY NUMBER :: 732-26-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H30-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1670 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Liver - other changes

REFERENCE :: SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949- Volume(issue)/page/year: 36(1-4),10,1989 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8580 mg/kg/10D-C

TOXIC EFFECTS :: Blood - hemorrhage Related to Chronic Data - death

REFERENCE :: JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 109,453,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10914 mg/kg/3W-C

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Blood - hemorrhage Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 46,935,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4377 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 211 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4377 No. of Facilities: 279 (estimated) No. of Industries: 4 No. of Occupations: 13 No. of Employees: 12085 (estimated) No. of Female Employees: 239 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H400
Precautionary Statements	P273-P301 + P312 + P330-P391
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36/37/39-S45-S60-S61-S24/25
RIDADR	UN 2430 8/PG 3
WGK Germany	3
RTECS	SN3570000
Packaging Group	III
Hazard Class	9

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 8
CAS#:1988-75-6 4-bromo-246-tri... CAS#:115-11-7 Isobutylene CAS#:108-95-2 Phenol CAS#:96-76-4 2,4-Di-t-butylphenol
CAS#:507-19-7 2-Bromo-2-methy... CAS#:513-35-9 2-Methylbut-2-ene CAS#:5457-60-3 2,5-Cyclohexadi... CAS#:75-21-8 ETHYLENE OXIDE
DownStream 9
CAS#:96-76-4 2,4-Di-t-butylphenol CAS#:1118-32-7 Propanamide,N-(... CAS#:75-65-0 tert-Butanol CAS#:34105-76-5 3,6-Di-tert-but...
CAS#:4714-62-9 4-(Methylamino)... CAS#:732-26-3 2,4,6-Tri-tert-... CAS#:1197-19-9 4-Dimethylamino... CAS#:5076-20-0 Oxirane,2,2,3,3...
CAS#:3315-32-0 2,4,6-tri-tert-...

This table lists relevant public references with title, journal and publication metadata for this compound.

In-vivo passive sampling to measure elimination kinetics in bioaccumulation tests.

Chemosphere 88(1) , 62-8, (2012)

The application of in-tissue passive sampling to quantify chemical kinetics in fish bioconcentration experiments was investigated. A passive sampler consisting of an acupuncture needle covered with a ...

Radical production and cytotoxic activity of tert-butyl-substituted phenols.

In Vitr. Mol. Toxicol. 14(1) , 53-63, (2001)

2,4,6-Tri-tert-butylphenol (TBP)-related compounds are used for stabilizing plastics by making them resistant to oxidation. However, the cytotoxic activity of these compounds has not yet been establis...

The role of low levels of water in the electrochemical oxidation of α-tocopherol (vitamin E) and other phenols in acetonitrile.

Phys. Chem. Chem. Phys. 13(28) , 12745-54, (2011)

The phenol, α-tocopherol, can be electrochemically oxidised in a -2e(-)/-H(+) process to form a diamagnetic cation that is long-lived in dry organic solvents such as acetonitrile and dichloromethane, ...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
Source: 824
External Id: ADRB2293

Name: Adrenergic beta2 receptor (ADRB2) small molecule antagonists, cell-based qHTS assay
Source: 824
External Id: ADRB2713

Total 213, Current Page 1 of 22

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

MFCD00008821

2,4,6-tri-tert-butyl phenol

2,4,6-Tri-tert-butylphenol

2,4,6-tritert-butylphenol

2,4,6-Tri-tert-butylbenzolol

EINECS 211-989-5

2,4,6-Tris(2-methyl-2-propanyl)phenol

2,4,6-TRI(TERT-BUTYL)PHENOL

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of 2,4,6-Tri-tert-butylphenol?

A: The English name of 2,4,6-Tri-tert-butylphenol is 2,4,6-Tri-tert-butylphenol.

Q: What is the molecular weight of 2,4,6-Tri-tert-butylphenol?

A: Molecular weight of 2,4,6-Tri-tert-butylphenol is 262.430.

Q: What is the CAS number of 2,4,6-Tri-tert-butylphenol?

A: CAS number of 2,4,6-Tri-tert-butylphenol is 732-26-3.

Q: What are the upstream materials of 2,4,6-Tri-tert-butylphenol?

A: Related upstream materials(CAS) of 2,4,6-Tri-tert-butylphenol: 1988-75-6;115-11-7;108-95-2;96-76-4;507-19-7;513-35-9;5457-60-3;75-21-8.

Q: What are the downstream products of 2,4,6-Tri-tert-butylphenol?

A: Related downstream products(CAS) of 2,4,6-Tri-tert-butylphenol: 96-76-4;1118-32-7;75-65-0;34105-76-5;4714-62-9;732-26-3;1197-19-9;5076-20-0;3315-32-0.

Q: What is the safety information for 2,4,6-Tri-tert-butylphenol?

A: Safety information for 2,4,6-Tri-tert-butylphenol: S26-S36/37/39-S45-S60-S61-S24/25.

Q: How is the water solubility of 2,4,6-Tri-tert-butylphenol?

A: Water solubility of 2,4,6-Tri-tert-butylphenol: insoluble.

Q: What is the melting point of 2,4,6-Tri-tert-butylphenol?

A: Melting point of 2,4,6-Tri-tert-butylphenol is 125-130 °C(lit.).

Q: What is the polar surface area (PSA) of 2,4,6-Tri-tert-butylphenol?

A: Polar surface area (PSA) of 2,4,6-Tri-tert-butylphenol is 20.23000.

Q: What is the boiling point of 2,4,6-Tri-tert-butylphenol?

A: Boiling point of 2,4,6-Tri-tert-butylphenol is 278.0±0.0 °C at 760 mmHg.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2,4,6-Tri-tert-butylphenol
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,4,6-Tri-tert-butylphenol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2,4,6-Tri-tert-butylphenol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 2,4,6-Tri-tert-butylphenol
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

Get all suppliers and price by the below link:

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2,4,6-Tri-tert-butylphenol

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Articles11

2,4,6-Tri-tert-butylphenolBioassay

Synonyms

2,4,6-Tri-tert-butylphenol | FAQ

2,4,6-Tri-tert-butylphenolfactory

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.