Dazoxiben
Modify Date: 2025-08-25 15:29:29
Dazoxiben structure
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Common Name | Dazoxiben | ||
|---|---|---|---|---|
| CAS Number | 74226-22-5 | Molecular Weight | 268.69600 | |
| Density | N/A | Boiling Point | 491.2ºC at 760 mmHg | |
| Molecular Formula | C12H13ClN2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 250.9ºC | |
Use of DazoxibenDazoxiben is a potent and orally active thromboxane (TX) synthase inhibitor[1]. |
| Name | 4-(2-imidazol-1-ylethoxy)benzoic acid,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Dazoxiben is a potent and orally active thromboxane (TX) synthase inhibitor[1]. |
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| Related Catalog | |
| Target |
Thromboxane (TX) synthase[1] |
| In Vitro | Dazoxiben inhibits TXB2 production in clotting human whole blood with an IC50 of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production[1]. Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC50 of 1.60 μM) than in rat whole blood (IC50= 0.32μM), and is not associated with changes in PGE2, PGF2 alpha and 6-keto-PGF1 alpha production[1]. |
| In Vivo | Dazoxiben (intraperitoneal administration; 100 μg/kg) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs[2]. |
| References |
| Boiling Point | 491.2ºC at 760 mmHg |
|---|---|
| Molecular Formula | C12H13ClN2O3 |
| Molecular Weight | 268.69600 |
| Flash Point | 250.9ºC |
| Exact Mass | 268.06100 |
| PSA | 64.35000 |
| LogP | 2.46230 |
| Hazard Codes | Xi |
|---|
|
~79%
Dazoxiben CAS#:74226-22-5 |
| Literature: Ono Pharmaceutical Co., Ltd. Patent: US4461905 A1, 1984 ; |
|
~84%
Dazoxiben CAS#:74226-22-5 |
| Literature: Cross, Peter E.; Dickinson, Roger P.; Parry, M. John; Randall, Michael J. Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1427 - 1432 |
|
~%
Dazoxiben CAS#:74226-22-5 |
| Literature: Cross, Peter E.; Dickinson, Roger P.; Parry, M. John; Randall, Michael J. Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1427 - 1432 |
|
~%
Dazoxiben CAS#:74226-22-5 |
| Literature: Biagi; Dell'Omodarme; Ferretti; Giorgi; Livi; Scartoni Farmaco, 1990 , vol. 45, # 11 p. 1181 - 1192 |
![1-acetyl-3-[2-(4-ethoxycarbonylphenoxy)ethyl]-imidazolium iodide structure](https://image.chemsrc.com/caspic/014/85938-29-0.png)
![4-[2-(1H-imidazol-1-yl)ethoxy]benzamide structure](https://image.chemsrc.com/caspic/203/75912-57-1.png)
![methyl 4-[2-(1H-imidazol-1-yl)-ethoxy]-benzoate structure](https://image.chemsrc.com/caspic/327/75912-98-0.png)
| Dazoxiben hydrochloride |
| Dazoxiben HCl |