Dazoxiben

Modify Date: 2025-08-25 15:29:29

Dazoxiben structure	Common Name	Dazoxiben
	CAS Number	74226-22-5	Molecular Weight	268.69600
	Density	N/A	Boiling Point	491.2ºC at 760 mmHg
	Molecular Formula	C₁₂H₁₃ClN₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	250.9ºC

Use of Dazoxiben

Dazoxiben is a potent and orally active thromboxane (TX) synthase inhibitor[1].

Name	4-(2-imidazol-1-ylethoxy)benzoic acid,hydrochloride
Synonym	More Synonyms

Description	Dazoxiben is a potent and orally active thromboxane (TX) synthase inhibitor[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
Target	Thromboxane (TX) synthase[1]
In Vitro	Dazoxiben inhibits TXB2 production in clotting human whole blood with an IC50 of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production[1]. Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC50 of 1.60 μM) than in rat whole blood (IC50= 0.32μM), and is not associated with changes in PGE2, PGF2 alpha and 6-keto-PGF1 alpha production[1].
In Vivo	Dazoxiben (intraperitoneal administration; 100 μg/kg) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs[2].
References	[1]. Patrignani P, et al. Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism.J Pharmacol Exp Ther. 1984 Feb;228(2):472-7. [2]. Yu SM, et al. Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor.Br J Pharmacol. 1994 Mar;111(3):906-12.

Boiling Point	491.2ºC at 760 mmHg
Molecular Formula	C₁₂H₁₃ClN₂O₃
Molecular Weight	268.69600
Flash Point	250.9ºC
Exact Mass	268.06100
PSA	64.35000
LogP	2.46230

Hazard Codes	Xi

1-acetyl-3-[2-(...

CAS#:85938-29-0

~79%

Dazoxiben

CAS#:74226-22-5

Literature: Ono Pharmaceutical Co., Ltd. Patent: US4461905 A1, 1984 ;

4-[2-(1H-imidaz...

CAS#:75912-57-1

~84%

Dazoxiben

CAS#:74226-22-5

Literature: Cross, Peter E.; Dickinson, Roger P.; Parry, M. John; Randall, Michael J. Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1427 - 1432

2-(4-carbamoylp...

CAS#:36616-30-5

Dazoxiben

CAS#:74226-22-5

Literature: Cross, Peter E.; Dickinson, Roger P.; Parry, M. John; Randall, Michael J. Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1427 - 1432

methyl 4-[2-(1H...

CAS#:75912-98-0

Dazoxiben

CAS#:74226-22-5

Literature: Biagi; Dell'Omodarme; Ferretti; Giorgi; Livi; Scartoni Farmaco, 1990 , vol. 45, # 11 p. 1181 - 1192

Dazoxiben hydrochloride

Dazoxiben HCl

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China
Product Name: Dazoxiben
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China
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Dazoxiben
Price: ￥Inquiry/1g
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Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: Dazoxiben
Price: ￥Inquiry/100mg ￥Inquiry/10mg ￥Inquiry/1g ￥Inquiry/1mg
Purity: 97.0%
Delivery: Inquiry
Contact: Xiyao Wang
Email: 406104890@qq.com

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Price: ￥600/1 mg

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Dazoxiben

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