Dazoxiben

• 常用名: Dazoxiben
• 英文名: Dazoxiben
• CAS号: 74226-22-5
• 分子量: 268.69600
• 密度: N/A
• 沸点: 491.2ºC at 760 mmHg
• 分子式: C₁₂H₁₃ClN₂O₃
• 熔点: N/A
• 闪点: 250.9ºC

Dazoxiben用途

Dazoxiben 是一种有效的口服活性血栓烷合酶 (thromboxane (TX) synthase) 抑制剂。

Dazoxiben名称

• 中文名: 4-(2-(1H-咪唑-1-基)乙氧基)苯甲酸盐酸盐
• 英文名: 4-(2-imidazol-1-ylethoxy)benzoic acid,hydrochloride

Dazoxiben生物活性

• 描述: Dazoxiben 是一种有效的口服活性血栓烷合酶 (thromboxane (TX) synthase) 抑制剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
  研究领域 >> 炎症/免疫
• 靶点实验:

  Thromboxane (TX) synthase[1]

• 体外研究: DZOXBEN抑制凝血全血中的TXB2生成,IC50为0.3μm,并导致PGE2的平行增强大于PGF2α大于6-酮-PGF1α生成(1)。DZOXBEN抑制大鼠肾小球中TXB2的产生,其IC50为1.60μm,与大鼠全血(IC50＝0.32μm)相比,与PGE2、PGF2α和6-酮-PGF1α生成的变化无关(1)。
• 体内研究: Dazoxiben(腹腔给药,100μg/kg)使尾部出血时间延长96.8±10.8秒(2)。
• 参考文献:

  [1]. Patrignani P, et al. Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism.J Pharmacol Exp Ther. 1984 Feb;228(2):472-7.

  [2]. Yu SM, et al. Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor.Br J Pharmacol. 1994 Mar;111(3):906-12.

Dazoxiben物理化学性质

• 沸点: 491.2ºC at 760 mmHg
• 分子式: C₁₂H₁₃ClN₂O₃
• 分子量: 268.69600
• 闪点: 250.9ºC
• 精确质量: 268.06100
• PSA: 64.35000
• LogP: 2.46230
• InChIKey: PVKDFUXBDJPRGU-UHFFFAOYSA-N
• SMILES: Cl.O=C(O)c1ccc(OCCn2ccnc2)cc1
• 储存条件: 2-8°C，惰性气体保存

Dazoxiben安全信息

• 危害码 (欧洲): Xi

Dazoxiben靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Validation... 来源：NMMLSC 靶标：ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens] External Id：UNMCMD_ABCB6_1o_ValidationSet

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

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Dazoxiben英文别名

• Dazoxiben hydrochloride
• Dazoxiben HCl