8-Geranyloxypsoralen

Modify Date: 2024-01-10 18:26:25

8-Geranyloxypsoralen Structure
8-Geranyloxypsoralen structure
Common Name 8-Geranyloxypsoralen
CAS Number 7437-55-0 Molecular Weight 338.397
Density 1.2±0.1 g/cm3 Boiling Point 503.7±50.0 °C at 760 mmHg
Molecular Formula C21H22O4 Melting Point N/A
MSDS USA Flash Point 258.4±30.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 8-Geranyloxypsoralen


8-Geranyloxypsoralen is a furanocoumarin isolated from grapefruit, acts as a potent inhibitor of P450 3A4 (CYP3A4) with an IC50 of 3.93 μM[1].

 Names

Name 9-((3,7-Dimethylocta-2,6-dien-1-yl)oxy)-7H-furo[3,2-g]chromen-7-one
Synonym More Synonyms

 8-Geranyloxypsoralen Biological Activity

Description 8-Geranyloxypsoralen is a furanocoumarin isolated from grapefruit, acts as a potent inhibitor of P450 3A4 (CYP3A4) with an IC50 of 3.93 μM[1].
Related Catalog
Target

IC50: 3.93 μM (P450 3A4)[1]

References

[1]. Row EC, et al. Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4. Bioorg Med Chem. 2006 Jun 1;14(11):3865-71.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 503.7±50.0 °C at 760 mmHg
Molecular Formula C21H22O4
Molecular Weight 338.397
Flash Point 258.4±30.1 °C
Exact Mass 338.151794
PSA 52.58000
LogP 5.85
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.583
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H317
Precautionary Statements P280
Hazard Codes Xn
Risk Phrases 22-43
Safety Phrases 36-37
RIDADR NONH for all modes of transport

 Synonyms

9-((3,7-Dimethylocta-2,6-dien-1-yl)-oxy)-7H-furo[3,2-g]chromen-7-one
8-Geranyloxy psoralen
7H-Furo(3,2-g)(1)benzopyran-7-one, 9-((3,7-dimethyl-2,6-octadienyl)oxy)-
7H-Furo[3,2-g][1]benzopyran-7-one, 9-[[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-
9-{[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one