Formamide

Modify Date: 2026-06-30 11:43:34

Formamide structure	Common Name	Formamide
	CAS Number	75-12-7	Molecular Weight	45.041
	Density	1.0±0.1 g/cm3	Boiling Point	210.5±9.0 °C at 760 mmHg
	Molecular Formula	CH₃NO	Melting Point	2-3 °C(lit.)
	MSDS	Chinese USA	Flash Point	81.1±18.7 °C
	Symbol	GHS08	Signal Word	Danger

Use of Formamide

Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	formamide
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.
Related Catalog	Signaling Pathways >> Others >> Others Biochemical Assay Reagents Research Areas >> Others

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.0±0.1 g/cm3
Boiling Point	210.5±9.0 °C at 760 mmHg
Melting Point	2-3 °C(lit.)
Molecular Formula	CH₃NO
Molecular Weight	45.041
Flash Point	81.1±18.7 °C
Exact Mass	45.021465
PSA	43.09000
LogP	-1.51
Vapour density	1.55 (vs air)
Vapour Pressure	0.2±0.4 mmHg at 25°C
Index of Refraction	1.370
InChIKey	ZHNUHDYFZUAESO-UHFFFAOYSA-N
SMILES	NC=O
Water Solubility	miscible

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Formamide MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ0525000

CHEMICAL NAME :: Formamide

CAS REGISTRY NUMBER :: 75-12-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 42

MOLECULAR FORMULA :: C-H3-N-O

MOLECULAR WEIGHT :: 45.05

WISWESSER LINE NOTATION :: ZVH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5577 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - ataxia Kidney, Ureter, Bladder - incontinence

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >13500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 3150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 910 mg/kg/26W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - liver function tests impaired Kidney, Ureter, Bladder - proteinuria

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 ppm/6H/2W-I

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count Blood - changes in platelet count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7980 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 1200 mg/kg

SEX/DURATION :: female 10-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 910 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Non-mammalian species Cells - not otherwise specified

REFERENCE :: CAANAT Comptes Rendus de l'Association des Anatomistes. (Nancy, France) V.1-56, 1899-1972. For publisher information, see ANOBAU. Volume(issue)/page/year: 56,712,1972 *** REVIEWS *** ACGIH TLV-TWA 18 mg/m3 (10 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (15 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 10 ppm (18 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 20 ppm (30 mg/m3) JAN 1993 OEL-FINLAND:TWA 20 ppm (37 mg/m3);STEL 30 ppm (55 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 20 ppm (30 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 20 ppm (30 mg/m3) JAN 1993 OEL-RUSSIA:STEL 3 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 20 ppm (37 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 20 ppm (30 mg/m3);STEL 30 ppm (45 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO FORMAMIDE-air:10H TWA 10 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84454 No. of Facilities: 227 (estimated) No. of Industries: 6 No. of Occupations: 14 No. of Employees: 3195 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84454 No. of Facilities: 42 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 2724 (estimated) No. of Female Employees: 556 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H351-H360D-H373
Precautionary Statements	P201-P281-P308 + P313
Target Organs	Blood
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T:Toxic
Risk Phrases	R61
Safety Phrases	S53-S45-S36/37/39-S26-S23
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	LQ0525000
HS Code	2924199090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

(Z)-Methanimidi...

CAS#:77287-34-4

Formamide

CAS#:75-12-7

Learn More

Literature: Maier, Guenther; Endres, Joerg European Journal of Organic Chemistry, 2000 , # 6 p. 1061 - 1063

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 1
CAS#:77287-34-4 (Z)-Methanimidi...
DownStream 0

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

RETRA exerts anticancer activity in Ewing's sarcoma cells independent of their TP53 status.

Eur. J. Cancer 51(7) , 841-51, (2015)

Mutant p53 can exert oncogenic activity by inhibitory interaction with p73. The small-molecule RETRA has been described to disrupt this interaction and to suppress carcinoma cells (Kravchenko et al., ...

Characterization of Pythium oligandrum populations that colonize the rhizosphere of vines from the Bordeaux region.

FEMS Microbiol. Ecol. 90(1) , 153-67, (2014)

This study focused on one oomycete, Pythium oligandrum, well-known for its plant protection abilities, which thrives in microbial environment where bacteria and fungal communities are also present. Th...

Proper migration and axon outgrowth of zebrafish cranial motoneuron subpopulations require the cell adhesion molecule MDGA2A.

Biol. Open 4(2) , 146-54, (2015)

The formation of functional neuronal circuits relies on accurate migration and proper axonal outgrowth of neuronal precursors. On the route to their targets migrating cells and growing axons depend on...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Formic amide

potassium deuteroformate

methanimidic acid

formamidic acid

MFCD00007941

Formamide

AMINOFORMALDEHYDE

Hydroxyformaldimin

Formimidsaeure

formic-d acid,potassium salt

EINECS 200-842-0

Formamine

formimidic acid

Kalium-d-formiat

Potassium formate-d

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the polar surface area (PSA) of formamide?

A: Polar surface area (PSA) of formamide is 43.09000.

Q: What is the molecular weight of formamide?

A: Molecular weight of formamide is 45.041.

Q: What is the molecular formula of formamide?

A: Molecular formula of formamide is CH3NO.

Q: What is the SMILES notation of formamide?

A: SMILES notation of formamide is NC=O.

Q: What are the uses of formamide?

A: Main uses of formamide: Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.

Q: What are the upstream materials of formamide?

A: Related upstream materials(CAS) of formamide: 77287-34-4.

Q: What is the InChIKey of formamide?

A: InChIKey of formamide is ZHNUHDYFZUAESO-UHFFFAOYSA-N.

Q: What English synonyms does formamide have?

A: English synonyms of formamide: Formic amide, potassium deuteroformate, methanimidic acid, formamidic acid, MFCD00007941, Formamide, AMINOFORMALDEHYDE, Hydroxyformaldimin, Formimidsaeure, formic-d acid,potassium salt, EINECS 200-842-0, Formamine, formimidic acid, Kalium-d-formiat, Potassium formate-d.

Q: What is the melting point of formamide?

A: Melting point of formamide is 2-3 °C(lit.).

Q: What is the CAS number of formamide?

A: CAS number of formamide is 75-12-7.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: formamide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Formamide
Price: ￥Inquiry/25kg
Purity: 99.5%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

Get all suppliers and price by the below link:

Formamide suppliers

Price: $50/100g

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