α-Ketoisovaleric acid

Modify Date: 2024-01-02 14:50:18

α-Ketoisovaleric acid Structure
α-Ketoisovaleric acid structure
Common Name α-Ketoisovaleric acid
CAS Number 759-05-7 Molecular Weight 116.115
Density 1.1±0.1 g/cm3 Boiling Point 170.2±9.0 °C at 760 mmHg
Molecular Formula C5H8O3 Melting Point N/A
MSDS N/A Flash Point 71.0±15.2 °C

 Use of α-Ketoisovaleric acid


3-Methyl-2-oxobutanoic acid is a precursor of pantothenic acid in Escherichia coli.

 Names

Name 3-methyl-2-oxobutanoic acid
Synonym More Synonyms

 α-Ketoisovaleric acid Biological Activity

Description 3-Methyl-2-oxobutanoic acid is a precursor of pantothenic acid in Escherichia coli.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro 3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) is a precursor of pantothenic acid in Escherichia coli[1]. 3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) enhances alpha-ketoisocaproic acid and alpha-keto-beta-methyl-n-valeric acid, but diminishes the corresponding amino acids, and causes an early decline of ornithine along with a late augmentation of plasma arginine[2].
In Vivo 3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) induces convulsions through GABAergic and glutamatergic mechanisms in rats[3].
References

[1]. MAAS WK, et al. alpha-Ketoisovaleric acid, a precursor of pantothenic acid in Escherichia coli. J Bacteriol. 1953 Apr;65(4):388-93.

[2]. Schauder P, et al. Oral administration of alpha-ketoisovaleric acid or valine in humans: blood kinetics and biochemical effects. J Lab Clin Med. 1984 Apr;103(4):597-605.

[3]. Coitinho AS, et al. Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. Brain Res. 2001 Mar 9;894(1):68-73.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 170.2±9.0 °C at 760 mmHg
Molecular Formula C5H8O3
Molecular Weight 116.115
Flash Point 71.0±15.2 °C
Exact Mass 116.047340
PSA 54.37000
LogP -0.36
Vapour Pressure 0.7±0.7 mmHg at 25°C
Index of Refraction 1.432
Storage condition 2-8°C

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: 3-Methyl-2-oxo-butanoic acid
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:3-Methyl-2-oxo-butanoic acid
CAS number:759-05-7

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C5H8O3
Molecular weight:116.1

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi
HS Code 2918300090

 Synthetic Route

 Customs

HS Code 2918300090
Summary 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Synonyms

a-keto-Isovaleric acid
Dimethylpyruvic acid
α-Oxo-β-methylbutyric acid
Butanoic acid, 3-methyl-2-oxo-
2-Ketoisovaleric acid
KETOVALINE
2-Oxo-3-methylbutyric acid
3-Methyl-2-oxo-butanoic Acid
Isopropylglyoxylic acid
a-Oxo-b-methylbutyric acid
a-keto-b-Methylbutyric acid
α-keto-β-Methylbutyric acid
a-Oxoisovaleric acid
3-methyl-2-oxo-Butyric acid
α-Oxoisovaleric acid
2-Oxo-3-methylbutanoic acid
3-Methyl-2-oxobutanoic acid
Top Suppliers:I want be here



Get all suppliers and price by the below link:

α-Ketoisovaleric acid suppliers


Price: ¥770/10 mM * 1 mL in DMSO

Reference only. check more α-Ketoisovaleric acid price