Bromocresol Green

Modify Date: 2026-06-29 18:22:25

Bromocresol Green Structure
Bromocresol Green structure
Common Name Bromocresol Green
CAS Number 76-60-8 Molecular Weight 698.01
Density 2.1±0.1 g/cm3 Boiling Point 626.0±55.0 °C at 760 mmHg
Molecular Formula C21H14Br4O5S Melting Point 225 °C
MSDS USA Flash Point 332.4±31.5 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

 Use of Bromocresol Green


Bromocresol green is a pH-sensitive triphenylmethane dye commonly used for the determination of protein and albumin in serum. Bromocresol green is a bio-based dye with a yellow-green to blue-green color. Bromocresol green turns yellow (λmax=435 nm, protonated form) when placed in acidic solution (e.g. pH=4.15), and turns blue in basic solution (λmax=615 nm, deprotonated form). Bromocresol green is widely used as a pH indicator in the field of biochemical analysis. In addition, Bromocresol green is also used to detect the concentration of molecules such as creatinine, and to judge the viability of cells[1][2][3][4].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name Bromocresol green
Synonym More Synonyms

 Bromocresol Green Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Bromocresol green is a pH-sensitive triphenylmethane dye commonly used for the determination of protein and albumin in serum. Bromocresol green is a bio-based dye with a yellow-green to blue-green color. Bromocresol green turns yellow (λmax=435 nm, protonated form) when placed in acidic solution (e.g. pH=4.15), and turns blue in basic solution (λmax=615 nm, deprotonated form). Bromocresol green is widely used as a pH indicator in the field of biochemical analysis. In addition, Bromocresol green is also used to detect the concentration of molecules such as creatinine, and to judge the viability of cells[1][2][3][4].
Related Catalog
References

[1]. Delanghe S, et al. Binding of bromocresol green and bromocresol purple to albumin in hemodialysis patients. Clin Chem Lab Med. 2018 Feb 23;56(3):436-440.  

[2]. Jurmanović S, et al. Organically modified silicate thin films doped with colourimetric pH indicators methyl red and bromocresol green as pH responsive sol–gel hybrid materials[J]. Thin Solid Films, 2010, 518(8): 2234-2240.

[3]. Chaiyo S, et al. A novel paper-based colorimetry device for the determination of the albumin to creatinine ratio. Analyst. 2018 Nov 5;143(22):5453-5460.  

[4]. Hou H, et al. Single-cell pH imaging and detection for pH profiling and label-free rapid identification of cancer-cells. Sci Rep. 2017 May 11;7(1):1759.  

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 2.1±0.1 g/cm3
Boiling Point 626.0±55.0 °C at 760 mmHg
Melting Point 225 °C
Molecular Formula C21H14Br4O5S
Molecular Weight 698.01
Flash Point 332.4±31.5 °C
Exact Mass 693.729492
PSA 92.21000
LogP 7.80
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.716
InChIKey FRPHFZCDPYBUAU-UHFFFAOYSA-N
SMILES Cc1c(C2(c3cc(Br)c(O)c(Br)c3C)OS(=O)(=O)c3ccccc32)cc(Br)c(O)c1Br
Storage condition Store at RT.
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility slightly soluble

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SJ7456000
CHEMICAL NAME :
Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-3 -methyl-, S,S-dioxide
CAS REGISTRY NUMBER :
76-60-8
BEILSTEIN REFERENCE NO. :
0372527
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C21-H14-Br4-O5-S
MOLECULAR WEIGHT :
698.05

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger
Hazard Statements H225-H319-H336
Precautionary Statements P210-P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S7-S16-S24/25-S26-S37/39
RIDADR UN 1219 3/PG 2
WGK Germany 3
RTECS SJ7456000
Hazard Class 3.0
HS Code 2934991000

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

~%

Bromocresol Green Structure

Bromocresol Green

CAS#:76-60-8

Learn More
Literature: Acta Physica et Chemica, , vol. 4, p. 73

~%

Bromocresol Green Structure

Bromocresol Green

CAS#:76-60-8

Learn More
Literature: Canadian Journal of Chemistry, , vol. 69, # 6 p. 937 - 944

 Precursor & DownStream

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor  3

DownStream  2

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2934991000
Summary 2934991000. sultones and sultams. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles53

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Chemical profile and in vivo hypoglycemic effects of Syzygium jambos, Costus speciosus and Tapeinochilos ananassae plant extracts used as diabetes adjuvants in Puerto Rico.

BMC Complement Altern. Med. 15 , 244, (2015)

The increasing numbers of people who use plant-based remedies as alternative or complementary medicine call for the validation of less known herbal formulations used to treat their ailments. Since Pue...

Synergistic topical application of salt-processed Phellodendron amurense and Sanguisorba officinalis Linne alleviates atopic dermatitis symptoms by reducing levels of immunoglobulin E and pro-inflammatory cytokines in NC/Nga mice.

Mol. Med. Report. 12 , 7657-64, (2015)

Atopic dermatitis is a chronic inflammatory skin disease, and salt-processed Phellodendron amurense (CPE) and Sanguisorba officinalis Linne (SOE) are widely used as anti-inflammatory agents in Asia. T...

Production of 4-ethylphenol in alperujo by Lactobacillus pentosus.

J. Sci. Food Agric. 95 , 2222-7, (2015)

Alperujo is the paste generated from the two-phase extraction system of olive oil. This wet pomace must be stored for several months and, during this period, the formation of 4-ethyphenol provokes a s...

 Bromocresol GreenBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

bromcresol green spray
m-Cresol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2,6-dibromo-, S,S-dioxide (8CI)
Bromocresol Green p.a.
MYCOBACTERIUM BOVIS
BCG
Bromcresol Green
BROMOCRESOL GREEN,ACS
2,2'-dimethyl-3,3',5,5'-tetrabromophenolsulfophthalein
EINECS 200-972-8
3',3'',5',5''-Tetrabromo-m-cresolsulfonephthalein
vertdebromocresol
2,2'-dimethyl-3,3',5,5'-tetrabromophenolsulphonephthalein
3',3",5',5"-tetrabromo-m-cresolsulfonapthalein
a,a-Bis(3,5-dibromo-4-hydroxy-o-tolyl)-a-hydroxytoluenesulfonic Acid g-Sultone
3′,3′′,5′,5′′-Tetrabromo-m-cresolsulfonephthalein
BCG,Mycobacterium bovis
4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis[2,6-dibromo-3-methylphenol] S,S-Dioxide
BBOT
3,3',5,5'-Tetrabromo-m-cresolsulfonphthalein
BROMOCRESOL BLUE
MFCD00005874
4,4'-(1,1-Dioxido-3H-2,1-benzoxathiole-3,3-diyl)bis(2,6-dibromo-3-methylphenol)
Bromocresol Green

 Bromocresol Green | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the LogP of Bromocresol green?
A: LogP of Bromocresol green is 7.80.
Q: What are the storage conditions for Bromocresol green?
A: Storage conditions for Bromocresol green: Store at RT.
Q: What is the safety information for Bromocresol green?
A: Safety information for Bromocresol green: S7-S16-S24/25-S26-S37/39.
Q: What is the molecular weight of Bromocresol green?
A: Molecular weight of Bromocresol green is 698.01.
Q: What is the InChIKey of Bromocresol green?
A: InChIKey of Bromocresol green is FRPHFZCDPYBUAU-UHFFFAOYSA-N.
Q: How is the water solubility of Bromocresol green?
A: Water solubility of Bromocresol green: slightly soluble.
Q: What is the CAS number of Bromocresol green?
A: CAS number of Bromocresol green is 76-60-8.
Q: What is the polar surface area (PSA) of Bromocresol green?
A: Polar surface area (PSA) of Bromocresol green is 92.21000.
Q: What is the melting point of Bromocresol green?
A: Melting point of Bromocresol green is 225 °C.
Q: What is the English name of Bromocresol green?
A: The English name of Bromocresol green is Bromocresol green.

 Bromocresol Greenfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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