Histrelin structure
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Common Name | Histrelin | ||
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CAS Number | 76712-82-8 | Molecular Weight | 1323.502 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | 1800.6ºC at 760 mmHg | |
Molecular Formula | C66H86N18O12 | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | 1042.8ºC | |
Symbol |
GHS08 |
Signal Word | Danger |
Use of HistrelinHistrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis[1][2][5]. |
Name | histrelin |
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Synonym | More Synonyms |
Description | Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis[1][2][5]. |
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Related Catalog | |
Target |
GnRH Receptor[1] |
In Vitro | Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants[4]. Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system[5]. |
In Vivo | Histrelin (0.1 mg/kg, subcutaneous injection) rescues the circulating LH concentrations in Csfmop/Csfmop mice[2]. Histrelin (10,30, or 100 μg /day, subcutaneous injection) reduces the number of endometrial glands and atrophied the stroma in rabbits[3]. Animal Model: Csfmop/Csfmop mice [2] Dosage: 0.001, 0.05, and 0.1 mg/kg Administration: Subcutaneous injection Result: Increased serum FSH concentrations by 4-fold. Animal Model: Rabbits[3] Dosage: 10, 30, or 100 μg /day Administration: Subcutaneous injection for 4 weeks Result: Caused a regression of the endometrial glands and a thinning of the stroma. |
References |
[1]. Emma D Deeks, et al. Histrelin: in advanced prostate cancer. Drugs. 2010 Mar 26;70(5):623-30. |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 1800.6ºC at 760 mmHg |
Molecular Formula | C66H86N18O12 |
Molecular Weight | 1323.502 |
Flash Point | 1042.8ºC |
Exact Mass | 1322.667236 |
PSA | 446.86000 |
LogP | 0.09 |
Index of Refraction | 1.701 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS08 |
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Signal Word | Danger |
Hazard Statements | H360 |
Precautionary Statements | P201-P308 + P313 |
Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
Hazard Codes | T: Toxic; |
Risk Phrases | R60 |
Safety Phrases | 53-22-36/37/39-45 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | OK6370800 |
HS Code | 2937190090 |
HS Code | 2937190090 |
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