Tigogenin

Modify Date: 2025-08-21 10:25:29

Tigogenin Structure
Tigogenin structure
 Common Name Tigogenin
CAS Number 77-60-1 Molecular Weight 416.637
Density 1.1±0.1 g/cm3 Boiling Point 516.6±20.0 °C at 760 mmHg
Molecular Formula C27H44O3 Melting Point 202-204ºC
MSDS N/A Flash Point 266.2±21.8 °C

 Use of Tigogenin


Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid drugs. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells[1].

 Names

Name (25R)-5.α.-Spirostan-3.β.-ol
Synonym More Synonyms

 Tigogenin Biological Activity

Description Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid drugs. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells[1].
Related Catalog
References

[1]. Zhou H, et al. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Mol Cell Endocrinol. 2007 May 30;270(1-2):17-22.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 516.6±20.0 °C at 760 mmHg
Melting Point 202-204ºC
Molecular Formula C27H44O3
Molecular Weight 416.637
Flash Point 266.2±21.8 °C
Exact Mass 416.329041
PSA 38.69000
LogP 6.21
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.552

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WH1443500
CHEMICAL NAME :
5-alpha-Spirostan-3-beta-ol, (25R)-
CAS REGISTRY NUMBER :
77-60-1
LAST UPDATED :
199709
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C27-H44-O3
MOLECULAR WEIGHT :
416.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29QKAZ "Toxins of Animal and Plant Origin, Proceedings International Symposium, 2nd, 1970," de Vries, A., and E. Kochva, eds., 3 vols., New York, Gordon and Breach Science Pub., 1971-73 Volume(issue)/page/year: 2,597,1972

 Safety Information

Hazard Codes Xi
RTECS WH1443500
Hazard Class 2.3
HS Code 2932999099

 Synthetic Route

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

5α-Spirostan-3β-ol, (25R)-
TIGOGENIN
Tsosarsasaprgein
(3β,5α,25R)-Spirostan-3-ol
MFCD00067287
Ticogenin
(25R)-5a-Spirostan-3b-ol
(25R)-5α-Spirostan-3β-ol
Sisalagenin
Trigonegenin B
EINECS 201-041-9
Spirostan-3-ol, (3β,5α,25R)-
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