Tigogenin

Modify Date: 2026-06-30 14:30:19

Tigogenin structure	Common Name	Tigogenin
	CAS Number	77-60-1	Molecular Weight	416.637
	Density	1.1±0.1 g/cm3	Boiling Point	516.6±20.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₄₄O₃	Melting Point	202-204ºC
	MSDS	N/A	Flash Point	266.2±21.8 °C

Use of Tigogenin

Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid drugs. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells[1].

Name	(25R)-5.α.-Spirostan-3.β.-ol
Synonym	More Synonyms

Description	Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid drugs. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Zhou H, et al. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Mol Cell Endocrinol. 2007 May 30;270(1-2):17-22.

Density	1.1±0.1 g/cm3
Boiling Point	516.6±20.0 °C at 760 mmHg
Melting Point	202-204ºC
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.637
Flash Point	266.2±21.8 °C
Exact Mass	416.329041
PSA	38.69000
LogP	6.21
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.552
InChIKey	GMBQZIIUCVWOCD-MFRNJXNGSA-N
SMILES	CC1CCC2(OC1)OC1CC3C4CCC5CC(O)CCC5(C)C4CCC3(C)C1C2C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH1443500

CHEMICAL NAME :: 5-alpha-Spirostan-3-beta-ol, (25R)-

CAS REGISTRY NUMBER :: 77-60-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C27-H44-O3

MOLECULAR WEIGHT :: 416.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29QKAZ "Toxins of Animal and Plant Origin, Proceedings International Symposium, 2nd, 1970," de Vries, A., and E. Kochva, eds., 3 vols., New York, Gordon and Breach Science Pub., 1971-73 Volume(issue)/page/year: 2,597,1972

Hazard Codes	Xi
RTECS	WH1443500
Hazard Class	2.3
HS Code	2932999099

Precursor 5
CAS#:512-04-9 Diosgenin CAS#:915-35-5 HECOGENIN ACETATE CAS#:690275-05-9 (E)-1-(tert-but... CAS#:110124-76-0 (25R)-5α-spiros...
CAS#:35959-24-1 (25R)-5α-spiros...
DownStream 4
CAS#:17916-30-2 Pregn-5-en-20-o... CAS#:571-20-0 5α-Androstane-3... CAS#:1169-20-6 (3β,5α)-20-Oxop... CAS#:1239-31-2 Epiandrosterone...

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Antifungal activity against Candida glabrata ATCC 48435 after 48 hrs by broth microdi...
Source: ChEMBL
Target: Nakaseomyces glabratus
External Id: CHEMBL1772884

Name: Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B1
External Id: CHEMBL3039488

Name: Inhibition of human NF-kappaB in HEK cells by luciferase reporter gene assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1918957

Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS

Name: Antifungal activity against Candida albicans ATCC 10231 assessed as reduction in grow...
Source: ChEMBL
Target: Candida albicans
External Id: CHEMBL1772879

Name: Antifungal activity against Cryptococcus neoformans ATCC 36556 assessed as reduction ...
Source: ChEMBL
Target: Cryptococcus neoformans
External Id: CHEMBL1772881

Name: Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B3
External Id: CHEMBL3039491

Name: Antifungal activity against Aspergillus fumigatus ATCC 16424 after 48 hrs by broth mi...
Source: ChEMBL
Target: Aspergillus fumigatus
External Id: CHEMBL1772882

Name: Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening
Source: 11827
Target: Phosphogluconate dehydrogenase
External Id: 6PGD_Inhibitor_Screening_2015_09

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TIGOGENIN

Tsosarsasaprgein

(3β,5α,25R)-Spirostan-3-ol

MFCD00067287

Ticogenin

(25R)-5a-Spirostan-3b-ol

(25R)-5α-Spirostan-3β-ol

Sisalagenin

Trigonegenin B

EINECS 201-041-9

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Tigogenin

Use of Tigogenin

Names

Tigogenin Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

TigogeninBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.