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China
Product Name: Tigogenin
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77-60-1

77-60-1 structure

77-60-1 structure

Name: Tigogenin
Chemical Name: (25R)-5.α.-Spirostan-3.β.-ol
CAS Number: 77-60-1
Molecular Formula: C₂₇H₄₄O₃
Molecular Weight: 416.637
Catalog: Natural product Steroidal compound
Create Date: 2018-09-30 20:25:24
Modify Date: 2026-06-30 14:30:19
Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid drugs. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells[1].

Name	(25R)-5.α.-Spirostan-3.β.-ol
Synonyms	(3,5,25R)-3-Hydroxy-spirostane TIGOGENIN (5alpha,25R)-spirostan-3beta-ol (25r)-5-alpha-spirostan-3-beta-o Ticogenin Sisalagenin 5-ALPHA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL (2aS,2'R,4S,5'R,6aS,6bS,8aS,8bR,9S,11aS,12aS,12bR)-5',6a,8a,9-TetraMethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol TIGOGENIN (: ) (5A,25R)-SPIROSTAN-3B-OL) Sisal saponin (3-beta,5-alpha,25r)-spirostan-3-ol Tsosarsasaprgein (3β,5α,25R)-Spirostan-3-ol Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran], spirostan-3-ol deriv (25R)-5-Spirostan-3-ol SMILAGENIN(RG) (25R)-5α-Spirostan-3β-ol 5alpha-Spirostan-3beta-ol, (25R) 5α, 20α, 22α, 25D-SPIROSTAN-3β-OL 5-alpha-spirostan-3-beta-ol MFCD00067287 (2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-Tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol (25R)-5a-Spirostan-3b-ol EINECS 201-041-9 Nsc93754 Tsossasaprgein (3-beta,5-alpha,25r)-spirostan-3-o 22-Isoallospirostan-3β-ol 25R,5ALPHA-SPIROSTAN-3BETA-OL (25R)-3β-Hydroxy-5α-spirostane Trigonegenin B Tigogenin-RM Spirostan-3-ol, (3beta,5alpha,25R)

Description	Tigogenin, one of steroidal sapogenins, is widely used for synthesizing steroid drugs. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Zhou H, et al. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Mol Cell Endocrinol. 2007 May 30;270(1-2):17-22.

Density	1.1±0.1 g/cm3
Boiling Point	516.6±20.0 °C at 760 mmHg
Melting Point	202-204ºC
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.637
Flash Point	266.2±21.8 °C
Exact Mass	416.329041
PSA	38.69000
LogP	6.21
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.552

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH1443500

CHEMICAL NAME :: 5-alpha-Spirostan-3-beta-ol, (25R)-

CAS REGISTRY NUMBER :: 77-60-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C27-H44-O3

MOLECULAR WEIGHT :: 416.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29QKAZ "Toxins of Animal and Plant Origin, Proceedings International Symposium, 2nd, 1970," de Vries, A., and E. Kochva, eds., 3 vols., New York, Gordon and Breach Science Pub., 1971-73 Volume(issue)/page/year: 2,597,1972

Hazard Codes	Xi
RTECS	WH1443500
Hazard Class	2.3
HS Code	2932999099

Precursor 5
512-04-9 915-35-5 690275-05-9 110124-76-0
35959-24-1
DownStream 4
17916-30-2 571-20-0 1169-20-6 1239-31-2

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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